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3- (methylamino)- 2- ((methylamino)methyl)propane- 1- thiol

a radioprotective agent; structure in first source

Also Known As:

Prc-210

Networked: 12 relevant articles (5 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol: 12
- Sulfur Compounds: 278
  - Sulfhydryl Compounds: 4168
    - 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol: 12

Experts

1.	Fahl, William E: 10 articles (01/2022 - 04/2012)
2.	Soref, Cheryl M: 3 articles (07/2013 - 04/2012)
3.	Goesch, Torsten R: 2 articles (01/2022 - 01/2021)
4.	Dreischmeier, Emma: 2 articles (01/2021 - 01/2020)
5.	Verhoven, Bret M: 2 articles (01/2021 - 08/2020)
6.	Wilson, Nancy A: 2 articles (01/2021 - 08/2020)
7.	Bath, Natalie M: 2 articles (08/2020 - 07/2019)
8.	Redfield, Robert R: 2 articles (08/2020 - 07/2019)
9.	Back, Susan: 2 articles (01/2020 - 01/2019)
10.	Hacker, Timothy A: 2 articles (01/2019 - 04/2012)

Related Diseases

1.	Ischemia 01/01/2019 - "Significant reduction of ischemia-reperfusion cell death in mouse myocardial infarcts using the immediate-acting PrC-210 ROS-scavenger." 01/01/2021 - "PrC-210 confers 100% survival to mice and rats that received an otherwise 100% lethal radiation dose and 36% reduction of ischemia-reperfusion-induced mouse myocardial infarct damage, and thus is a viable candidate to prevent human ROS-induced ischemia-reperfusion and ionizing radiation toxicities. " 07/01/2019 - "Significant Reduction of Murine Renal Ischemia-Reperfusion Cell Death Using the Immediate-Acting PrC-210 Reactive Oxygen Species Scavenger."
2.	Carcinogenesis 01/01/2020 - "In this study, we address whether the new PrC-210 ROS-scavenger is effective in protecting p53-deficient (p53-/-) mice against X-ray-induced accelerated tumor mortality; this is the most sensitive radiation tumorigenesis model currently known. "
3.	Neoplasms (Cancer) 01/01/2020 - "Findings revealed that when administered 25 min before 4 Gy X-ray irradiation, PrC-210 reduced DNA damage (c-H2AX foci) by 40%, and in a notable coincidence, caused a 40% shift in tumor latency/incidence, and the 0.5 MTD PrC210 dose had no discernible toxicities in these p53-/- mice. " 01/01/2020 - "Impact of the PrC-210 Radioprotector Molecule on Cancer Deaths in p53-Deficient Mice." 01/01/2020 - "In this study, we address whether the new PrC-210 ROS-scavenger is effective in protecting p53-deficient (p53-/-) mice against X-ray-induced accelerated tumor mortality; this is the most sensitive radiation tumorigenesis model currently known. "
4.	Reperfusion Injury 08/01/2020 - "These findings support further development of the PrC-210 molecule to suppress or to prevent ischemia-reperfusion injury in organ transplant and other ischemia-reperfusion injury settings." 01/01/2019 - "In a series of both in vitro and in vivo experiments, we show that: (a) in vitro, PrC-210 was the most potent and effective ROS-scavenger when functionally compared to eight of the most commonly studied antioxidants in the MI literature, (b) in vitro PrC-210 ROS-scavenging efficacy was both immediate (seconds) and long-lasting (hours), which would make it effective in both (1) real-time (seconds), as post-MI or cardiac surgery hearts are reperfused with PrC-210-containing blood, and (2) long-term (hours), as hearts are bathed with systemic PrC-210 after MI or surgery, (c) systemic PrC-210 caused a significant 36% reduction of mouse cardiac muscle death following a 45-minute cardiac IR insult; in a striking coincidence, the PrC-210 36% reduction in cardiac muscle death equals the 36% of the MI-induced cardiac cell death estimated 6 years ago by Ovize and colleagues to result from "reperfusion injury," (d) hearts in PrC-210-treated mice performed better than controls after heart attacks when functionally analyzed using echocardiography, and (e) the PrC-210 ROS-scavenging mechanism of action was corroborated by its ability to prevent >85% of the direct, H2O2-induced killing of neonate cardiomyocytes in cell culture. "
5.	Myocardial Infarction 01/01/2019 - "Significant reduction of ischemia-reperfusion cell death in mouse myocardial infarcts using the immediate-acting PrC-210 ROS-scavenger." 01/01/2021 - "PrC-210 confers 100% survival to mice and rats that received an otherwise 100% lethal radiation dose and 36% reduction of ischemia-reperfusion-induced mouse myocardial infarct damage, and thus is a viable candidate to prevent human ROS-induced ischemia-reperfusion and ionizing radiation toxicities. " 01/01/2019 - "In a series of both in vitro and in vivo experiments, we show that: (a) in vitro, PrC-210 was the most potent and effective ROS-scavenger when functionally compared to eight of the most commonly studied antioxidants in the MI literature, (b) in vitro PrC-210 ROS-scavenging efficacy was both immediate (seconds) and long-lasting (hours), which would make it effective in both (1) real-time (seconds), as post-MI or cardiac surgery hearts are reperfused with PrC-210-containing blood, and (2) long-term (hours), as hearts are bathed with systemic PrC-210 after MI or surgery, (c) systemic PrC-210 caused a significant 36% reduction of mouse cardiac muscle death following a 45-minute cardiac IR insult; in a striking coincidence, the PrC-210 36% reduction in cardiac muscle death equals the 36% of the MI-induced cardiac cell death estimated 6 years ago by Ovize and colleagues to result from "reperfusion injury," (d) hearts in PrC-210-treated mice performed better than controls after heart attacks when functionally analyzed using echocardiography, and (e) the PrC-210 ROS-scavenging mechanism of action was corroborated by its ability to prevent >85% of the direct, H2O2-induced killing of neonate cardiomyocytes in cell culture. "

Related Drugs and Biologics

1.	Antioxidants
2.	Sulfhydryl Compounds (Thiols)
3.	Caspases
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	DNA (Deoxyribonucleic Acid)
6.	University of Wisconsin-lactobionate solution
7.	Amifostine (Ethyol)
8.	Propylene Glycol (1,2 Propanediol)
9.	Cytokines
10.	Free Radical Scavengers

Related Therapies and Procedures

1.	Transplantation
2.	Controlled Hypotension