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EC 0746

an antiarthritis agent; structure in first source

Also Known As:

EC-0746; EC0746

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Folic Acid: 19425
        EC 0746: 2
        Aminopterin: 248
        EC 0746: 2

Experts

1.	Cross, Vicky A: 2 articles (01/2014 - 04/2011)
2.	Leamon, Christopher P: 2 articles (01/2014 - 04/2011)
3.	Lu, Yingjuan: 2 articles (01/2014 - 04/2011)
4.	Stinnette, Torian W: 2 articles (01/2014 - 04/2011)
5.	Vlahov, Iontcho R: 2 articles (01/2014 - 04/2011)
6.	Westrick, Elaine: 2 articles (01/2014 - 04/2011)
7.	Hahn, Spencer J: 1 article (01/2014)
8.	Vaughn, Jeremy F: 1 article (01/2014)
9.	Wheeler, Leroy W: 1 article (01/2014)
10.	Wollak, Kristin N: 1 article (01/2014)

Related Diseases

1.	Uveitis 01/01/2014 - "In this report, EC0746's effectiveness was evaluated against experimental retinal S-antigen (PDSAg) induced autoimmune uveitis (EAU) and myelin-basic-protein induced autoimmune encephalomyelitis (EAE). "
2.	Encephalomyelitis (Myeloencephalitis) 01/01/2014 - "In this report, EC0746's effectiveness was evaluated against experimental retinal S-antigen (PDSAg) induced autoimmune uveitis (EAU) and myelin-basic-protein induced autoimmune encephalomyelitis (EAE). "
3.	Rheumatoid Arthritis 04/04/2011 - "The EC0746 anti-inflammatory activity, pharmacokinetics, and toxicity were also evaluated in normal rats or in rats with adjuvant-induced arthritis; that is, a FR-positive macrophage model that closely resembles rheumatoid arthritis in humans. "
4.	Arthritis (Polyarthritis) 04/04/2011 - "The EC0746 anti-inflammatory activity, pharmacokinetics, and toxicity were also evaluated in normal rats or in rats with adjuvant-induced arthritis; that is, a FR-positive macrophage model that closely resembles rheumatoid arthritis in humans. " 04/04/2011 - "In the macrophage-rich rat arthritis model, brief treatment with subcutaneously administered EC0746 is shown to mediate an FR-specific anti-inflammatory response that is more potent than either orally administered methotrexate or subcutaneously delivered etanercept. "

Related Drugs and Biologics

1.	Arrestin
2.	Methotrexate (Mexate)
3.	Myelin Basic Protein
4.	Etanercept (Enbrel)