Cold Hypersensitivity

Recurrent attacks of maculopapular rash arthralgias, myalgias, fever, chills, and swelling of the extremities after exposure to cold that are associated with Familial Cold Autoinflammatory Syndrome 1, which is caused by mutations in the NLRP3 gene. OMIM: 120100

Networked: 182 relevant articles (10 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neuralgia (Stump Neuralgia)
2.	Pain (Aches)
3.	Hyperalgesia
4.	Hypersensitivity (Allergy)
5.	Wounds and Injuries (Trauma)

Experts

1.	Taylor, Bradley K: 6 articles (01/2021 - 09/2007)
2.	Nakagawa, Takayuki: 6 articles (12/2019 - 07/2012)
3.	Linderoth, Bengt: 5 articles (09/2019 - 05/2006)
4.	Eschalier, Alain: 5 articles (01/2018 - 10/2008)
5.	Kaneko, Shuji: 5 articles (01/2018 - 07/2012)
6.	Dickenson, Anthony H: 5 articles (01/2016 - 10/2005)
7.	Wiesenfeld-Hallin, Zsuzsanna: 5 articles (10/2014 - 12/2003)
8.	Xu, Xiao-Jun: 5 articles (10/2014 - 12/2003)
9.	Geppetti, Pierangelo: 4 articles (12/2020 - 07/2011)
10.	So, Kanako: 4 articles (01/2020 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cold Hypersensitivity:

1.	Oxaliplatin (Eloxatin)FDA LinkGeneric 06/27/2023 - "In addition, MTM reversed both short-term and long-term (1 month) oxaliplatin-induced mechanical and cold hypersensitivity, without the rescue of intraepidermal nerve fiber loss. " 01/01/2019 - "It was found that CBN and OST inhibited both mechanical and cold hypersensitivity induced by oxaliplatin. " 01/01/2019 - "Three days after oxaliplatin treatment in Macaca fascicularis, a significantly reduced response latency to cold (10 °C) water was observed, indicating cold hypersensitivity. " 11/01/2018 - "Oxaliplatin causes acute cold hypersensitivity in most patients. " 02/01/2018 - "Cold hypersensitivity is the hallmark of oxaliplatin-induced neuropathy, so we used a preclinical model of oxaliplatin-induced cold hypersensitivity in rats to determine the effects of oxaliplatin on TRP channels. "
2.	Pregabalin (Lyrica)FDA Link 04/01/2010 - "Pregabalin successfully decreased mechanical and cold hypersensitivity, as a pre-treatment, but was less effective at suppressing cold hypersensitivity when administered as a post-treatment. " 04/01/2010 - "and systemic administration of pregabalin were effective in reducing the behavioral hypersensitivity, with the exception of systemic post-treatment on cold hypersensitivity. " 04/01/2010 - "We assessed the effectiveness of pregabalin at decreasing mechanical and cold hypersensitivity induced in a rat model of neuropathic pain. " 01/25/2021 - "Therefore, for the attenuation of cold hypersensitivity duloxetine seems to be a better than pregabalin therapeutic option. " 10/01/2008 - "Our results show that pregabalin may be a good choice to treat cold hypersensitivity after one oxaliplatin injection."
3.	TeaIBA 09/01/2016 - "Fermented green tea is helpful for cold hypersensitivity. " 09/01/2016 - "However, further studies are necessary to evaluate the long-term effects of the fermented green tea for cold hypersensitivity and to elucidate the underlying physiological mechanism."
4.	ojeok-sanIBA 11/29/2018 - "The findings of this study should provide meaningful information for a further large-scale, randomized controlled trial to confirm the safety and efficacy of Ojeok-san on cold hypersensitivity in the hands and feet in female patients. " 11/29/2018 - "This study aims to evaluate the safety, efficacy, and feasibility of a full randomized clinical trial of Ojeok-san in Korean female patients with cold hypersensitivity in the hands and feet. " 11/29/2018 - "Efficacy and safety of Ojeok-san in Korean female patients with cold hypersensitivity in the hands and feet: study protocol for a randomized, double-blinded, placebo-controlled, multicenter pilot study."
5.	NC-4016IBA 01/01/2014 - "The present study demonstrated that the antitumor efficacy of NC-4016 was superior to that of oxaliplatin in a mouse model of human carcinoma cell line KB. In addition, NC-4016-treated rats did not develop acute cold hypersensitivity, which is frequently experienced by patients after oxaliplatin administration. "
6.	Dizocilpine Maleate (Dizocilpine)IBA 10/01/2001 - "treatment with either MK-801 or (S)-4CPG produced a significant reduction in mechanical and cold hypersensitivity, as well as [3H]-PDBu binding in laminae I-II and III-VI of the lumbar spinal cord, after CCI. "
7.	Calcium Channels (Calcium Channel)IBA 02/01/2016 - "Although the therapeutic drug pregabalin is beneficial for preventing peripheral neuropathic pain by targeting the voltage-dependent calcium channel α2δ-1 (Cavα2δ-1) subunit, the effect of oxaliplatin-induced acute cold hypersensitivity is uncertain. "
8.	Retinaldehyde (Retinal)IBA 02/01/2021 - "We provide the first evidence for protective effects of AOC3 inhibition on STZ-induced pancreatic beta cell damage, neuropathic cold hypersensitivity and diabetic retinal dysfunction. " 02/01/2021 - "injections) were protective against STZ-induced pancreatic beta cell damage determined by insulin immunohistochemistry and radioimmunoassay, neuropathic cold hypersensitivity measured by paw withdrawal latency decrease from 0 °C water, and retinal dysfunction detected by electroretinography. "
9.	Proteins (Proteins, Gene)FDA Link 02/10/2023 - "The treatments reduced leukocyte migration, nitric oxide production, protein extravasation, edema, mechanical hyperalgesia, pain in both phases (neurogenic and inflammatory), cold hypersensitivity, and improved wound closure and tissue regeneration. "
10.	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/10/2023 - "The treatments reduced leukocyte migration, nitric oxide production, protein extravasation, edema, mechanical hyperalgesia, pain in both phases (neurogenic and inflammatory), cold hypersensitivity, and improved wound closure and tissue regeneration. "

Therapies and Procedures

1.	Injections 05/19/2009 - "Here we show that local injections of CQ produce mechanical hyperalgesia and cold hypersensitivity through a mechanism involving TRPA1 in mice. " 09/05/2014 - "Acute venlafaxine injections (20 and 40 mg/kg i.p.) on the 7th, 14th and 21st postoperative days could not reduce tactile and cold hypersensitivity significantly compared to CCI group. " 02/01/2021 - "injections) were protective against STZ-induced pancreatic beta cell damage determined by insulin immunohistochemistry and radioimmunoassay, neuropathic cold hypersensitivity measured by paw withdrawal latency decrease from 0 °C water, and retinal dysfunction detected by electroretinography. " 02/01/2016 - "By contrast, in rats, no significant cold hypersensitivity, or increased responsiveness to acetone applied to the hind paws, was observed 3 days after the first injection of oxaliplatin (5 mg/kg, i.p., once per day, two injections). " 09/01/2002 - "In the present study, we examined the effects of intrathecal pretreatment (twice daily injections on postoperative (PO) days 0-3 with the selective Group I (mGluR1a) mGluR antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid ((RS)-AIDA), the selective Group I (mGluR5a) antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP), the selective Group II mGluR agonist, (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate ((2R,4R)-APDC) or the selective Group III mGluR agonist, L-2-amino-4-phosphonobutyrate (L-AP4), on mechanical and cold hypersensitivity associated with chronic constriction injury (CCI) of the sciatic nerve in rats. "
2.	Aftercare (After-Treatment) 01/01/2016 - "From the 20 patients, who returned questionnaires at all assessment points, 9 reported a small and three reported a moderate improvement in cold hypersensitivity after treatment. " 01/01/2016 - "The McCabe Cold Sensitivity Severity scale (CSS) was used to measure cold hypersensitivity twice before treatment, at four weeks, and at one year after treatment; Likert scales was used for the patients ratings of improvements. " 02/01/2016 - "Oxaliplatin-induced acute cold hypersensitivity 4 days after treatment was significantly inhibited by pregabalin (50 mg/kg, p.o.). "
3.	Ligation 06/26/2008 - "The present study provides several lines of evidence that TRPA1 receptors are expressed on intact primary sensory neurons and contribute to cold hypersensitivity following spinal nerve ligation (SNL). " 01/01/2016 - "The preventive effect of resiniferatoxin on the development of cold hypersensitivity induced by spinal nerve ligation: involvement of TRPM8." 10/01/2005 - "Thus SP-SAP attenuated the tactile and cold hypersensitivity and abnormal neuronal coding (including spontaneous activity, expansion of receptive field size) seen after spinal nerve ligation. " 01/01/2016 - "Resiniferatoxin (RTX) is a potent analog of capsaicin and activates transient receptor potential (TRP) vanilloid type (TRPV) 1. In the current study, we investigated the preventive effect of perineural RTX on the development of cold hypersensitivity induced by spinal nerve ligation (SNL) in rats. " 09/01/2007 - "After either partial sciatic nerve ligation (PSNL) or spared nerve injury (SNI), we found that unilateral or bilateral microinjection of lidocaine into the RVM reduced not only mechanical allodynia (decreased threshold to von Frey hairs and/or an automated device) and mechanical hyperalgesia (increased paw lifting in response to a noxious pin), but also cold hypersensitivity (increased lifting in response to the hindpaw application of a drop of acetone). "
4.	Sympathectomy (Sympathectomies) 01/01/2021 - "This study was conducted to evaluate the short-term as well as long-term efficacy, complications, and patient satisfaction of chemical lumbar sympathectomy during treatment cold hypersensitivity in the hands and feet. " 01/01/2021 - "A retrospective study of 72 patients with cold hypersensitivity in the hands and feet who received chemical lumbar sympathectomy treatment in our hospital from January 2015 to October 2018 was conducted. " 01/01/2021 - "CT-guided Chemical Lumbar Sympathectomy in the Treatment of Cold Hypersensitivity in the Hands and Feet." 01/01/2022 - "Comparison of Efficacy and Safety of Lumbar Sympathetic Radiofrequency Thermocoagulation Versus Chemical Lumbar Sympathectomy in the Treatment of Cold Hypersensitivity in the Hands and Feet: A Retrospective Study." 01/01/2021 - "Chemical lumbar sympathectomy is a valid treatment option for cold hypersensitivity in hands and feet, and computed tomography-guided percutaneous puncture chemical lumbar sympathectomy has the advantages of high success rate, less invasion, less complications, and repeatablity."
5.	Electroacupuncture 03/01/2014 - "Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats." 03/01/2014 - "This study investigated whether and how electroacupuncture (EA) attenuates cold hypersensitivity (allodynia) in a rat model of oxaliplatin-induced neuropathic pain. "