3- (5- (4- (cyclopentyloxy)- 2- hydroxybenzoyl)- 2- ((3- hydroxy- 1,2- benzisoxazol- 6- yl)methoxy)phenyl)propionic acid

an antiarthritic agent that inhibits c-Fos/activator protein-1; structure in first source

Also Known As:

T 5224; T-5224; T5224

Networked: 16 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Benzophenones: 60
    - 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1,2-benzisoxazol-6-yl)methoxy)phenyl)propionic acid: 16
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzophenones: 60
        3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1,2-benzisoxazol-6-yl)methoxy)phenyl)propionic acid: 16
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1,2-benzisoxazol-6-yl)methoxy)phenyl)propionic acid: 16

Experts

1.	Shiozawa, Shunichi: 5 articles (01/2018 - 05/2012)
2.	Aikawa, Yukihiko: 2 articles (01/2018 - 12/2017)
3.	Kimura, Tomoatsu: 2 articles (01/2018 - 12/2017)
4.	Motomura, Hiraku: 2 articles (01/2018 - 12/2017)
5.	Nogami, Makiko: 2 articles (01/2018 - 12/2017)
6.	Seki, Shoji: 2 articles (01/2018 - 12/2017)
7.	Chen, Zongyu: 1 article (01/2022)
8.	He, Shuang: 1 article (01/2022)
9.	Jiang, Wenqing: 1 article (01/2022)
10.	Xue, Chunju: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "In the present study, we demonstrated that inhibiting this cascade by targeting FOS using FOS inhibitor T-5224 suppressed mutant TERT cancer cells and tumors by inducing robust cell apoptosis; these did not occur in wild-type TERT cells and tumors. " 08/01/2021 - "Here we investigated the anti-tumor effect and mechanism of T-5224, an inhibitor of c-Fos/AP-1, on TNBC. " 01/01/2020 - "In MDA-MB-231 and HCC70 cells, combined treatment with eribulin and T-5224 showed a stronger anticancer effect than treatment with eribulin alone in cell growth assays, cell death assays and a mouse xenograft tumor model, whereas T-5224 alone showed no anticancer effect. "
2.	Osteoarthritis 01/01/2018 - "The objective of the present study is to demonstrate that a newly developed selective c-Fos/activator protein (AP)-1 inhibitor, T-5224, inhibits the expression of matrix metalloproteinases (MMPs) in human articular chondrocytes, and prevents cartilage destruction in an osteoarthritis (OA)-induced mouse model. "
3.	Neoplasm Metastasis (Metastasis) 10/05/2022 - "Using both xenograft and PDO metastasis models, we repurposed T5224 for treatment, a c-fos pharmacologic inhibitor investigated in clinical trials for arthritis, and observed suppression of metastases in BRMS1v2A273V/A273V LUAD in mice. "
4.	Lymphatic Metastasis 05/01/2016 - "In conclusion, T-5224 inhibited the invasion and migration of HNSCC cells in vitro, and prevented lymph node metastasis in head and neck cancer in an animal model. " 05/01/2016 - "Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model." 05/01/2016 - "The purpose of our study was to assess the therapeutic effects of a novel selective AP-1 inhibitor, T-5224, in preventing lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) in an orthotopic mouse model. "
5.	Inflammation (Inflammations) 01/06/2022 - "This study investigated whether T-5224 attenuates VILI in rats by inhibiting inflammation and apoptosis. "

Related Drugs and Biologics

1.	Matrix Metalloproteinases (MMPs)
2.	Transcription Factor AP-1 (Transcription Factor AP 1)
3.	Therapeutic Uses
4.	Proteins (Proteins, Gene)
5.	Gelatin
6.	2- (2- methoxy- 4- nitrophenyl)- 3- (4- nitrophenyl)- 5- (2,4- disulfophenyl)- 2H tetrazolium monosodium salt
7.	Interleukin-6 (Interleukin 6)
8.	Messenger RNA (mRNA)
9.	Peptides (Polypeptides)
10.	Minocycline (Cyclops)

Related Therapies and Procedures

1.	Punctures
2.	Spinal Injections
3.	Oral Administration