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importazole

an importin-8 inhibitor; structure in first source

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - importazole: 8

Experts

1.	Wong, Richard W: 2 articles (04/2020 - 01/2018)
2.	Abdulkareem, Angham Abdulrahman: 1 article (01/2021)
3.	Naseer, Muhammad Imran: 1 article (01/2021)
4.	Pushparaj, Peter Natesan: 1 article (01/2021)
5.	Hazawa, Masaharu: 1 article (04/2020)
6.	Kashiwakura, Ikuo: 1 article (04/2020)
7.	Nakagawa, Yuta: 1 article (04/2020)
8.	Nitta, Keisuke: 1 article (04/2020)
9.	Sato, Mariko: 1 article (04/2020)
10.	Sato, Yoshiaki: 1 article (04/2020)

Related Diseases

1.	Squamous Cell Carcinoma of Head and Neck 04/08/2020 - "The major findings of this study are that (i) blockage of KPNB1 specifically enhanced the radiation-induced apoptosis and radiosensitivity of HNSCC cells; (ii) importazole elevated p53-upregulated modulator of apoptosis (PUMA) expression via blocking the nuclear import of SCC-specific oncogene ΔNp63 in HNSCC cells; and (iii) blockage of KPNB1 attenuated the upregulation of cell surface PD-L1 expression on irradiated HNSCC cells. "
2.	Neoplasms (Cancer) 01/01/2019 - "Moreover, the intravenously administration of importazole, a specific inhibitor for KPNB1, effectively reduced PCa tumor size and weight in mice inoculated with PC3 PCa cells. " 01/01/2018 - "Treatment with Importazole, an importin β inhibitor, impeded tumor aggressiveness, presenting a potential therapeutic strategy." 01/01/2020 - "Drug-inducible importin β1 knockdown sensitizes HeLa cells to TRAIL-induced cell death in vitro, and exerts an antitumor effect when combined with agonistic anti-hDR5 antibody administration in vivo Therapeutic importin β1 knockdown, administered via the atelocollagen delivery system, as well as treatment with the importin β inhibitor, importazole, induced regression and/or eradication of two human TRAIL-resistant tumor cells when combined with agonistic anti-hDR5 antibody treatment. "
3.	Rectal Neoplasms (Rectal Cancer) 01/01/2020 - "Meanwhile, we also detected 5 common chemicals between colon and rectal cancer, including methylnitronitrosoguanidine, isoniazid, PD 0325901, sulindac sulfide, and importazole. "
4.	Multiple Myeloma 04/01/2013 - "The nuclear receptor inhibitor importazole inhibits proliferation and induces apoptosis of multiple myeloma cells by blocking the NF-κB signal pathway in vitro. " 04/01/2013 - "To investigate the effect of nuclear receptor inhibitor importazole (IPZ) on cell cycle and apoptosis of multiple myeloma (MM) cells and its regulatory mechanisms. " 04/01/2013 - "[Effect of nuclear receptor inhibitor importazole on the proliferation and apoptosis of multiple myeloma cells]."
5.	Cysts 01/01/2020 - "Importazole and Ivermectin, two known specific inhibitors of importins, separately influenced the encysting process by inducing an arrest in the trophozoite stage that prevents the production of cysts. "

Related Drugs and Biologics

1.	Karyopherins (Importin)
2.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
3.	Methylnitronitrosoguanidine (MNNG)
4.	Ivermectin (Mectizan)
5.	Isoniazid (Ftivazide)
6.	Camptothecin
7.	mirdametinib
8.	atelocollagen
9.	sulindac sulfide
10.	withaferin A