Abstract |
Nuclear pores are nanomachines acting as gatekeepers of molecular transport across nuclear membranes. In a recent issue of Cell, Rodriguez- Bravo et al. (2018) demonstrates that nuclear pores promote aggressive prostate cancer by snowballing POM121-importin β-driven nuclear import. Treatment with Importazole, an importin β inhibitor, impeded tumor aggressiveness, presenting a potential therapeutic strategy.
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Authors | Kee Siang Lim, Richard W Wong |
Journal | Cell chemical biology
(Cell Chem Biol)
Vol. 25
Issue 9
Pg. 1056-1058
(09 20 2018)
ISSN: 2451-9448 [Electronic] United States |
PMID | 30241601
(Publication Type: Journal Article, Comment)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Chemical References |
- E2F1 Transcription Factor
- E2F1 protein, human
- Membrane Glycoproteins
- Nuclear Pore Complex Proteins
- POM121 protein, human
- beta Karyopherins
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Topics |
- Active Transport, Cell Nucleus
- E2F1 Transcription Factor
- Humans
- Male
- Membrane Glycoproteins
- Nuclear Pore
- Nuclear Pore Complex Proteins
- Prostatic Neoplasms
- beta Karyopherins
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