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Targeting Nucleoporin POM121-Importin β Axis in Prostate Cancer.

Abstract
Nuclear pores are nanomachines acting as gatekeepers of molecular transport across nuclear membranes. In a recent issue of Cell, Rodriguez-Bravo et al. (2018) demonstrates that nuclear pores promote aggressive prostate cancer by snowballing POM121-importin β-driven nuclear import. Treatment with Importazole, an importin β inhibitor, impeded tumor aggressiveness, presenting a potential therapeutic strategy.
AuthorsKee Siang Lim, Richard W Wong
JournalCell chemical biology (Cell Chem Biol) Vol. 25 Issue 9 Pg. 1056-1058 (09 20 2018) ISSN: 2451-9448 [Electronic] United States
PMID30241601 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2018 Elsevier Ltd. All rights reserved.
Chemical References
  • E2F1 Transcription Factor
  • E2F1 protein, human
  • Membrane Glycoproteins
  • Nuclear Pore Complex Proteins
  • POM121 protein, human
  • beta Karyopherins
Topics
  • Active Transport, Cell Nucleus
  • E2F1 Transcription Factor
  • Humans
  • Male
  • Membrane Glycoproteins
  • Nuclear Pore
  • Nuclear Pore Complex Proteins
  • Prostatic Neoplasms
  • beta Karyopherins

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