NAV1.1 Voltage-Gated Sodium Channel

A voltage-gated sodium channel subtype that is predominantly expressed in the CENTRAL NERVOUS SYSTEM. Defects in the SCN1A gene which codes for the alpha subunit of this sodium channel are associated with DRAVET SYNDROME, generalized epilepsy with febrile seizures plus, type 2 (GEFS+2), and familial hemiplegic migraine type 3.

Also Known As:

NAV1.1 alpha Subunit; SCN1A Sodium Channel alpha Subunit; Sodium Channel, Voltage-Gated, Type I, alpha Protein; Type 1 Voltage-Gated Sodium Channel; Voltage-Gated Sodium Channel Type 1; Voltage-Gated Sodium Channel Type 1 alpha Subunit; NAV1.1 Voltage Gated Sodium Channel; Type 1 Voltage Gated Sodium Channel; Voltage Gated Sodium Channel Type 1; Voltage Gated Sodium Channel Type 1 Subunit alpha; Voltage Gated Sodium Channel Type 1 alpha Subunit; alpha Subunit, NAV1.1; Voltage-Gated Sodium Channel Type 1 Subunit alpha

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Sodium Channels: 2798
        Voltage-Gated Sodium Channels: 1295
        NAV1.1 Voltage-Gated Sodium Channel: 9
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Ion Channels: 6731
        Sodium Channels: 2798
        Voltage-Gated Sodium Channels: 1295
        NAV1.1 Voltage-Gated Sodium Channel: 9
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Sodium Channels: 2798
        Voltage-Gated Sodium Channels: 1295
        NAV1.1 Voltage-Gated Sodium Channel: 9
  - Nerve Tissue Proteins: 2
    - Voltage-Gated Sodium Channels: 1295
      - NAV1.1 Voltage-Gated Sodium Channel: 9

rat Scn1a protein

Bio-Agent Context: Research Results