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chrysosplenol D

structure in first source

Also Known As:

3',4',5-trihydroxy-3,6,7-trimethoxyflavone

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Pyrans: 131
    - Benzopyrans: 198
      - Chromones: 161
        Flavonoids: 10180
        Flavones: 456
        chrysosplenol D: 7
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 198
      - Chromones: 161
        Flavonoids: 10180
        Flavones: 456
        chrysosplenol D: 7

Experts

1.	Hafner, Susanne: 2 articles (06/2020 - 09/2019)
2.	Lang, Sophia J: 2 articles (06/2020 - 09/2019)
3.	Paetz, Christian: 2 articles (06/2020 - 09/2019)
4.	Schmidt, Christoph Q: 2 articles (06/2020 - 09/2019)
5.	Schmiech, Michael: 2 articles (06/2020 - 09/2019)
6.	Simmet, Thomas: 2 articles (06/2020 - 09/2019)
7.	Syrovets, Tatiana: 2 articles (06/2020 - 09/2019)
8.	Werner, Katharina: 2 articles (06/2020 - 09/2019)
9.	Gao, Cheng: 1 article (10/2023)
10.	Li, Yilei: 1 article (10/2023)

Related Diseases

1.	Acute Lung Injury 10/01/2021 - "This study investigated the effect and mechanism of chrysosplenol D (CD) on LPS-induced acute lung injury in mice. " 10/01/2021 - "Chrysosplenol D protects mice against LPS-induced acute lung injury by inhibiting oxidative stress, inflammation, and apoptosis via TLR4-MAPKs/NF-κB signaling pathways."
2.	Squamous Cell Carcinoma of Head and Neck 08/27/2021 - "This study investigated the anticancer property of chrysosplenol D and its underlying mechanism in oral squamous cell carcinoma (OSCC). " 08/27/2021 - "Chrysosplenol D Triggers Apoptosis through Heme Oxygenase-1 and Mitogen-Activated Protein Kinase Signaling in Oral Squamous Cell Carcinoma."
3.	Prostatic Neoplasms (Prostate Cancer) 10/01/2023 - "To uncover the effects of chrysosplenol D (CHD) on the progression of prostate cancer in vitro as well as in mice. " 10/01/2023 - "Chrysosplenol D can inhibit the growth of prostate cancer by inducing reactive oxygen species and autophagy." 06/08/2020 - "PC-3 prostate cancer cells exhibiting high basal protein kinase B (AKT) and no ERK1/2 activation were relatively resistant, whereas MDA-MB-231 cells with high basal ERK1/2 and low AKT activity were more sensitive to chrysosplenol d treatment. "
4.	Neoplasms (Cancer) 06/08/2020 - "In vivo, chrysosplenol d and casticin inhibited MDA-MB-231 tumor growth on chick chorioallantoic membranes. " 08/01/2005 - "Six flavonoids, persicogenin (1), artemetin (2), luteolin (3), penduletin (4), vitexicarpin (5) and chrysosplenol-D (6), have been isolated for the first time as new cell cycle inhibitors from Vitex trifolia L., a Chinese folk medicine used to treat cancers, through a bioassay-guided separation procedure. "
5.	Breast Neoplasms (Breast Cancer) 06/08/2020 - "Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells." 09/01/2019 - "Likewise, the extract's most abundant ingredients, chrysosplenol D, arteannuin B, and casticin, but not arteannuic acid or 6,7-dimethoxycoumarin, inhibited the viability of MDA-MB-231 breast cancer cells. "

Related Drugs and Biologics

1.	casticin
2.	Heme Oxygenase-1
3.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
4.	Luteolin
5.	Mitogen-Activated Protein Kinases
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Indomethacin (Indometacin)
8.	Flavonoids
9.	Dexamethasone (Maxidex)
10.	Croton Oil

Related Therapies and Procedures

1.	Traditional Medicine (Folk Remedies)