Cerebral Cavernous Malformations 2

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
- Neurologic Manifestations: 7102
  - Neurobehavioral Manifestations: 1586
    - Intellectual Disability: 8035
      - Cerebral Cavernous Malformations 2: 4
Signs and Symptoms Pathological Conditions
- Signs and Symptoms
  - Neurologic Manifestations: 7102
    - Neurobehavioral Manifestations: 1586
      - Intellectual Disability: 8035
        Cerebral Cavernous Malformations 2: 4
Behavior and Behavior Mechanisms
- Neurobehavioral Manifestations: 1586
  - Intellectual Disability: 8035
    - Cerebral Cavernous Malformations 2: 4
Mental Disorders: 24177
- Neurodevelopmental Disorders: 3095
  - Intellectual Disability: 8035
    - Cerebral Cavernous Malformations 2: 4
Musculoskeletal Diseases: 719
- Musculoskeletal Abnormalities: 43
  - Craniofacial Abnormalities: 203
    - Maxillofacial Abnormalities: 10
      - Jaw Abnormalities: 10
        Micrognathism: 338
        Cerebral Cavernous Malformations 2: 4
- Jaw Diseases: 15
  - Jaw Abnormalities: 10
    - Micrognathism: 338
      - Cerebral Cavernous Malformations 2: 4
Stomatognathic Diseases: 705
- Jaw Diseases: 15
  - Jaw Abnormalities: 10
    - Micrognathism: 338
      - Cerebral Cavernous Malformations 2: 4
- Stomatognathic System Abnormalities
  - Maxillofacial Abnormalities: 10
    - Jaw Abnormalities: 10
      - Micrognathism: 338
        Cerebral Cavernous Malformations 2: 4
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Musculoskeletal Abnormalities: 43
    - Craniofacial Abnormalities: 203
      - Maxillofacial Abnormalities: 10
        Jaw Abnormalities: 10
        Micrognathism: 338
        Cerebral Cavernous Malformations 2: 4
  - Stomatognathic System Abnormalities
    - Maxillofacial Abnormalities: 10
      - Jaw Abnormalities: 10
        Micrognathism: 338
        Cerebral Cavernous Malformations 2: 4
Musculoskeletal System
- Skeleton
  - Bone and Bones
    - Rib Cage
      - Ribs
        Cerebral Cavernous Malformations 2: 4

Related Diseases

1.	Central Nervous System Cavernous Hemangioma
2.	Cerebral Cavernous Malformations 3
3.	Cerebrovascular Disorders (Cerebrovascular Occlusion)

Experts

1.	Boggon, Titus J: 3 articles (01/2020 - 05/2014)
2.	Fisher, Oriana S: 3 articles (01/2020 - 05/2014)
3.	Liu, Weizhi: 2 articles (01/2020 - 01/2015)
4.	Zhang, Rong: 2 articles (01/2020 - 01/2015)
5.	Li, Xiaofeng: 1 article (01/2020)
6.	Akitake, Yoshiharu: 1 article (01/2017)
7.	Ando, Koji: 1 article (01/2017)
8.	Fukuhara, Shigetomo: 1 article (01/2017)
9.	Hino, Jun: 1 article (01/2017)
10.	Hosoda, Hiroshi: 1 article (01/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cerebral Cavernous Malformations 2:

1.	Proteins (Proteins, Gene)FDA Link 01/30/2015 - "The protein products of KRIT1 and CCM2 (Krev interaction trapped 1 (KRIT1) and cerebral cavernous malformations 2 (CCM2), respectively) directly interact with each other. " 01/01/2020 - "Cerebral cavernous malformations (CCM) are dysplasias that primarily occur in the neurovasculature, and are associated with mutations in three genes: KRIT1, CCM2, and PDCD10, the protein products of which are KRIT1 (Krev/Rap1 Interaction Trapped 1; CCM1, cerebral cavernous malformations 1), CCM2 (cerebral cavernous malformations 2; OSM, osmosensing scaffold for MEKK3), and CCM3 (cerebral cavernous malformations 3; PDCD10, programmed cell death 10). " 05/01/2014 - "These genes encode for the proteins KRIT1/CCM1 (krev interaction trapped 1/cerebral cavernous malformations 1), cerebral cavernous malformations 2, osmosensing scaffold for MEKK3 (CCM2/malcavernin/OSM), and cerebral cavernous malformations 3/programmed cell death 10 (CCM3/PDCD10). " 01/01/2017 - "p21-activated kinase 4 (PAK4) and cerebral cavernous malformations 2 (CCM2), a scaffold protein involved in a cerebrovascular disease, were required for the phosphorylation of MLC and promotion of cell spreading by ANP. "
2.	p21-Activated KinasesIBA 01/01/2017 - "p21-activated kinase 4 (PAK4) and cerebral cavernous malformations 2 (CCM2), a scaffold protein involved in a cerebrovascular disease, were required for the phosphorylation of MLC and promotion of cell spreading by ANP. "
3.	Atrial Natriuretic Factor (ANF)IBA 01/01/2017 - "p21-activated kinase 4 (PAK4) and cerebral cavernous malformations 2 (CCM2), a scaffold protein involved in a cerebrovascular disease, were required for the phosphorylation of MLC and promotion of cell spreading by ANP. "