Adult Nonimmune Chronic Idiopathic Neutropenia

Also Known As:

Neutropenia, Nonimmune Chronic Idiopathic, Adult; NI-CINA; Nonimmune Chronic Idiopathic Neutropenia of Adults

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Hemic and Lymphatic Diseases: 6
- Hematologic Diseases: 3366
  - Cytopenia: 2582
    - Leukopenia: 5826
      - Agranulocytosis: 4051
        Neutropenia: 16591
        Adult Nonimmune Chronic Idiopathic Neutropenia: 5
  - Leukocyte Disorders: 8
    - Leukopenia: 5826
      - Agranulocytosis: 4051
        Neutropenia: 16591
        Adult Nonimmune Chronic Idiopathic Neutropenia: 5
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Adult Nonimmune Chronic Idiopathic Neutropenia: 5

Related Diseases

1.	Adult Nonimmune Chronic Idiopathic Neutropenia
2.	Iron-Deficiency Anemia (Anemia, Iron Deficiency)
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
4.	Inflammation (Inflammations)
5.	Chronic Disease (Chronic Diseases)

Experts

1.	Eliopoulos, G D: 5 articles (01/2002 - 10/2000)
2.	Papadaki, H A: 5 articles (01/2002 - 10/2000)
3.	Psyllaki, M: 2 articles (01/2002 - 01/2001)
4.	Eliopoulos, D G: 2 articles (04/2001 - 01/2001)
5.	Alexandrakis, M: 1 article (01/2002)
6.	Gemetzi, C: 1 article (01/2002)
7.	Kosteas, T: 1 article (01/2002)
8.	Valatas, V: 1 article (04/2001)
9.	Coulocheri, S A: 1 article (01/2001)
10.	Spyropoulou, M: 1 article (01/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adult Nonimmune Chronic Idiopathic Neutropenia:

1.	CytokinesIBA 10/01/2000 - "Patients with NI-CINA have significant changes in serum immunoglobulins and some inflammation-related cytokines. " 10/01/2000 - "To study the changes in serum immunoglobulins and some closely related pro-inflammatory cytokines in patients with nonimmune chronic idiopathic neutropenia of adults (NI-CINA). " 04/01/2001 - "Two of the anemic patients had iron deficiency anemia (8.7%), 11 had anemia of chronic disease (ACD; 47.8%) presenting with normal or slightly reduced erythrocytic indices, low serum iron, and increased serum ferritin, and the remaining ten had anemia of undefined pathogenesis (AUP; 43.5%) with normal or slightly decreased erythrocytic indices, serum iron ranging from 43 to 88 microg/dl, and ferritin values ranging from 12 to 50 ng/ml. We conclude that ACD is the more frequent type of anemia seen in patients with NI-CINA, and that pro-inflammatory cytokines, notably TNF-alpha, may be involved in the pathogenesis of both ACD and AUP, given that serum levels of the cytokine were significantly increased and that the EPO response to anemia was blunted in these patients. "
2.	Immunoglobulins (Immunoglobulin)IBA 10/01/2000 - "Patients with NI-CINA have significant changes in serum immunoglobulins and some inflammation-related cytokines. " 10/01/2000 - "To study the changes in serum immunoglobulins and some closely related pro-inflammatory cytokines in patients with nonimmune chronic idiopathic neutropenia of adults (NI-CINA). "
3.	AutoantibodiesIBA 01/01/2001 - "This study describes the frequency of serum organ-specific and organ-nonspecific autoantibodies in 157 patients with nonimmune chronic idiopathic neutropenia of adults (NI-CINA). "
4.	HLA-DRB1 Chains (HLA DRB1)IBA 01/15/2001 - "Increased frequency of HLA-DRB1*1302 haplotype in patients with nonimmune chronic idiopathic neutropenia of adults."
5.	Transforming Growth Factor beta1 (TGF beta 1)IBA 10/01/2000 - "Increased serum IgA and decreased IgG3 strongly correlate with increased serum TGF-beta1 levels in patients with nonimmune chronic idiopathic neutropenia of adults." 10/01/2000 - "Serum levels of gamma-globulins, IgG, IgA, IgM, IgG subclasses, interleukin-4 (IL-4), interferon-gamma (IFN-gamma) and transforming growth factor-beta1 (TGF-beta1) were evaluated in 83 NI-CINA patients and 65 normal controls using the respective conventional methods. "
6.	Interleukin-1beta (Interleukin 1 beta)IBA 04/01/2001 - "We found that NI-CINA patients had low hemoglobin levels and increased serum concentrations of erythropoietin (EPO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta). "
7.	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/01/2002 - "Two patients with nonimmune chronic idiopathic neutropenia of adults developing acute myeloid leukemia with aberrant phenotype and complex karyotype but no mutations in granulocyte colony-stimulating factor receptor."
8.	Interleukin-4 (Interleukin 4)IBA 10/01/2000 - "Serum levels of gamma-globulins, IgG, IgA, IgM, IgG subclasses, interleukin-4 (IL-4), interferon-gamma (IFN-gamma) and transforming growth factor-beta1 (TGF-beta1) were evaluated in 83 NI-CINA patients and 65 normal controls using the respective conventional methods. "
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/01/2001 - "We found that NI-CINA patients had low hemoglobin levels and increased serum concentrations of erythropoietin (EPO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta). " 04/01/2001 - "Two of the anemic patients had iron deficiency anemia (8.7%), 11 had anemia of chronic disease (ACD; 47.8%) presenting with normal or slightly reduced erythrocytic indices, low serum iron, and increased serum ferritin, and the remaining ten had anemia of undefined pathogenesis (AUP; 43.5%) with normal or slightly decreased erythrocytic indices, serum iron ranging from 43 to 88 microg/dl, and ferritin values ranging from 12 to 50 ng/ml. We conclude that ACD is the more frequent type of anemia seen in patients with NI-CINA, and that pro-inflammatory cytokines, notably TNF-alpha, may be involved in the pathogenesis of both ACD and AUP, given that serum levels of the cytokine were significantly increased and that the EPO response to anemia was blunted in these patients. "
10.	IronIBA 04/01/2001 - "Two of the anemic patients had iron deficiency anemia (8.7%), 11 had anemia of chronic disease (ACD; 47.8%) presenting with normal or slightly reduced erythrocytic indices, low serum iron, and increased serum ferritin, and the remaining ten had anemia of undefined pathogenesis (AUP; 43.5%) with normal or slightly decreased erythrocytic indices, serum iron ranging from 43 to 88 microg/dl, and ferritin values ranging from 12 to 50 ng/ml. We conclude that ACD is the more frequent type of anemia seen in patients with NI-CINA, and that pro-inflammatory cytokines, notably TNF-alpha, may be involved in the pathogenesis of both ACD and AUP, given that serum levels of the cytokine were significantly increased and that the EPO response to anemia was blunted in these patients. "