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Thromboxane Synthetase Deficiency

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Hemic and Lymphatic Diseases: 6
- Hematologic Diseases: 3366
  - Blood Coagulation Disorders: 167
    - Thromboxane Synthetase Deficiency: 3
  - Blood Platelet Disorders: 126
    - Thromboxane Synthetase Deficiency: 3
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - Intramolecular Oxidoreductases
      - Thromboxane-A Synthase: 359
        Thromboxane Synthetase Deficiency: 3

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Thromboxane Synthetase Deficiency:

1.	Calcium IonophoresIBA 03/01/1981 - "These findings indicate that the TxA2 defect in this patient does not result from a thromboxane synthetase deficiency, but may be due to impaired mobilization of platelet calcium, and thus are consistent with the possibility that TxA2 may act as a calcium ionophore."
2.	Thromboxane B2IBA 09/01/1981 - "The decreased production of thromboxane B2, HHT and malondialdehyde and increased formation of prostaglandin F2a, E2, D2 and of 6-keto PGF1a are compatible with a partial platelet thromboxane synthetase deficiency and reorientation of cyclic endoperoxide metabolism. "
3.	Thromboxane A2 (A2, Thromboxane)IBA 02/01/1981 - "The findings indicate that the hereditary primary release disorder is probably due to a reduced thromboxane A2 production secondary to thromboxane synthetase deficiency. "
4.	ProstaglandinsIBA 09/01/1981 - "The decreased production of thromboxane B2, HHT and malondialdehyde and increased formation of prostaglandin F2a, E2, D2 and of 6-keto PGF1a are compatible with a partial platelet thromboxane synthetase deficiency and reorientation of cyclic endoperoxide metabolism. "
5.	Malondialdehyde (Propanedial)IBA 09/01/1981 - "The decreased production of thromboxane B2, HHT and malondialdehyde and increased formation of prostaglandin F2a, E2, D2 and of 6-keto PGF1a are compatible with a partial platelet thromboxane synthetase deficiency and reorientation of cyclic endoperoxide metabolism. "
6.	CalciumIBA 03/01/1981 - "These findings indicate that the TxA2 defect in this patient does not result from a thromboxane synthetase deficiency, but may be due to impaired mobilization of platelet calcium, and thus are consistent with the possibility that TxA2 may act as a calcium ionophore."