Complementation Group G Xeroderma Pigmentosum

mutation in ERCC5

Also Known As:

Xeroderma Pigmentosum, Complementation Group G; Xeroderma Pigmentosum VII

Networked: 20 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Precancerous Conditions: 304
  - Xeroderma Pigmentosum: 1866
    - Complementation Group G Xeroderma Pigmentosum: 20
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Skin Abnormalities: 159
    - Xeroderma Pigmentosum: 1866
      - Complementation Group G Xeroderma Pigmentosum: 20
- Inborn Genetic Diseases: 11939
  - Genetic Skin Diseases: 47
    - Xeroderma Pigmentosum: 1866
      - Complementation Group G Xeroderma Pigmentosum: 20
Skin and Connective Tissue Diseases
- Skin Diseases: 13127
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - DNA Repair-Deficiency Disorders: 538
    - Xeroderma Pigmentosum: 1866
      - Complementation Group G Xeroderma Pigmentosum: 20

Related Diseases

1.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
2.	Complementation Group D Xeroderma Pigmentosum

Experts

1.	Ibuki, Yuko: 2 articles (07/2022 - 01/2022)
2.	Komaki, Yukako: 2 articles (07/2022 - 01/2022)
3.	Bhattacharya, Deep: 1 article (08/2022)
4.	Pal, Riasha: 1 article (08/2022)
5.	Paul, Nilanjan: 1 article (08/2022)
6.	Rakshit, Sudeshna: 1 article (08/2022)
7.	Sarkar, Koustav: 1 article (08/2022)
8.	Shanmugam, Geetha: 1 article (08/2022)
9.	Suganuma, Koki: 1 article (07/2022)
10.	Lans, Hannes: 1 article (03/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Complementation Group G Xeroderma Pigmentosum:

1.	Proteins (Proteins, Gene)FDA Link 08/01/2022 - "One such protein is Xeroderma Pigmentosum Complementation Group G (XPG), a significant component in the Nucleotide Excision Repair (NER) pathway. " 04/21/2000 - "We also analyzed the role of the xeroderma pigmentosum, complementation group G (XPG) protein in the excision step of BER. " 06/01/1994 - "The human XPG (ERCC5) gene encodes a large acidic protein that corrects the ultraviolet light sensitivity of cells from both xeroderma pigmentosum complementation group G and rodent ERCC group 5. Here we characterize five XPG sequence alterations and a minor splicing defect in XP-G patient XP125LO. " 07/01/2022 - "The recruitment of NER proteins (transcription factor IIH, and xeroderma pigmentosum complementation group G) to DNA damage sites was inhibited by DBAN, which was further exacerbated by BSO treatment. " 05/01/2007 - "Mildly affected individuals from xeroderma pigmentosum complementation group G (XP-G) possess single amino acid substitutions in the XPG protein that adversely affects its 3' endonuclease function in nucleotide excision repair. "
2.	EndonucleasesIBA 01/01/2023 - "To increase the burden of spontaneous DNA damage, we knocked out the DNA repair endonucleases xeroderma pigmentosum complementation group G (XPG) and excision repair cross-complementation group 1 (ERCC1), either systemically or cardiomyocyte-restricted, and studied the effects on cardiac function and structure. " 03/01/2022 - "The XPG/ERCC5 endonuclease was originally identified as the causative gene for Xeroderma Pigmentosum complementation group G. " 05/01/2007 - "Mildly affected individuals from xeroderma pigmentosum complementation group G (XP-G) possess single amino acid substitutions in the XPG protein that adversely affects its 3' endonuclease function in nucleotide excision repair. " 07/08/1999 - "Xeroderma pigmentosum complementation group G (XPG) protein is a junction-specific endonuclease which is indispensable for nucleotide excision repair (NER) of DNA in eukaryotes. " 04/01/2010 - "FENs (flap endonucleases) and related FEN-like enzymes [EXO-1 (exonuclease-1), GEN-1 (gap endonuclease 1) and XPG (xeroderma pigmentosum complementation group G)] are a family of bivalent-metal-ion-dependent nucleases that catalyse structure-specific hydrolysis of DNA duplex-containing nucleic acid structures during DNA replication, repair and recombination. "
3.	DNA (Deoxyribonucleic Acid)IBA 11/01/2014 - "The xeroderma pigmentosum complementation group G (XPG) gene plays an important role in the DNA nucleotide excision repair (NER) pathway. " 07/08/1999 - "Xeroderma pigmentosum complementation group G (XPG) protein is a junction-specific endonuclease which is indispensable for nucleotide excision repair (NER) of DNA in eukaryotes. " 01/01/2022 - "DBAN treatment delayed the recruitment of NER proteins, transcription factor IIH (TFIIH) and xeroderma pigmentosum complementation group G (XPG), to DNA damaged sites, and subsequent gap filling process. " 04/01/2010 - "FENs (flap endonucleases) and related FEN-like enzymes [EXO-1 (exonuclease-1), GEN-1 (gap endonuclease 1) and XPG (xeroderma pigmentosum complementation group G)] are a family of bivalent-metal-ion-dependent nucleases that catalyse structure-specific hydrolysis of DNA duplex-containing nucleic acid structures during DNA replication, repair and recombination. "
4.	Transcription Factor TFIIHIBA 07/01/2022 - "The recruitment of NER proteins (transcription factor IIH, and xeroderma pigmentosum complementation group G) to DNA damage sites was inhibited by DBAN, which was further exacerbated by BSO treatment. " 01/01/2022 - "DBAN treatment delayed the recruitment of NER proteins, transcription factor IIH (TFIIH) and xeroderma pigmentosum complementation group G (XPG), to DNA damaged sites, and subsequent gap filling process. "
5.	Flap EndonucleasesIBA 06/01/2016 - "Flap endonuclease GEN homolog 1 (GEN1) is a HJ resolvase that belongs to the Rad2/xeroderma pigmentosum complementation group G nuclease family. " 04/01/2010 - "FENs (flap endonucleases) and related FEN-like enzymes [EXO-1 (exonuclease-1), GEN-1 (gap endonuclease 1) and XPG (xeroderma pigmentosum complementation group G)] are a family of bivalent-metal-ion-dependent nucleases that catalyse structure-specific hydrolysis of DNA duplex-containing nucleic acid structures during DNA replication, repair and recombination. "
6.	PlatinumIBA 08/03/2016 - "We investigated the impact of 2 SNPs of excision repair cross-complementation group 1 and 2 of xeroderma pigmentosum complementation group G on the outcome in patients with non-small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy. " 01/26/2015 - "We conducted a cohort study to investigate whether 3 potential single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene could predict the survival of advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based doublet chemotherapy. "
7.	STAT1 Transcription FactorIBA 12/01/1998 - "Physical and genetic linkage of glutaminase (Gls), signal transducer and activator of transcription 1 (Stat1), and xeroderma pigmentosum complementation group G (Xpg) on mouse proximal chromosome 1."
8.	Recombinases (Recombinase)IBA 06/01/2016 - "Flap endonuclease GEN homolog 1 (GEN1) is a HJ resolvase that belongs to the Rad2/xeroderma pigmentosum complementation group G nuclease family. "
9.	Messenger RNA (mRNA)IBA 12/01/2016 - "To explore the expression of xeroderma pigmentosum complementation group G （XPG） gene in healthy Han population of different ages and to analysis the relationship between the mRNA and protein expression levels of XPG and age, which may provide a new molecular-biological indicator for forensic age determination. "
10.	Nucleic AcidsIBA 04/01/2010 - "FENs (flap endonucleases) and related FEN-like enzymes [EXO-1 (exonuclease-1), GEN-1 (gap endonuclease 1) and XPG (xeroderma pigmentosum complementation group G)] are a family of bivalent-metal-ion-dependent nucleases that catalyse structure-specific hydrolysis of DNA duplex-containing nucleic acid structures during DNA replication, repair and recombination. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 08/03/2016 - "We investigated the impact of 2 SNPs of excision repair cross-complementation group 1 and 2 of xeroderma pigmentosum complementation group G on the outcome in patients with non-small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy. " 01/26/2015 - "We conducted a cohort study to investigate whether 3 potential single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene could predict the survival of advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based doublet chemotherapy. "
2.	Treatment Delay 01/01/2022 - "DBAN treatment delayed the recruitment of NER proteins, transcription factor IIH (TFIIH) and xeroderma pigmentosum complementation group G (XPG), to DNA damaged sites, and subsequent gap filling process. "