DNA repair gene polymorphisms in non-small-cell lung cancer patients treated with first-line platinum-containing chemotherapy.

Abstract

PURPOSE:

Single nucleotide polymorphisms (SNPs) in the DNA repair genes are believed to contribute to the clinical outcome of patients receiving platinum-based chemotherapy. We investigated the impact of 2 SNPs of excision repair cross-complementation group 1 and 2 of xeroderma pigmentosum complementation group G on the outcome in patients with non-small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy.

METHODS:

Between October 2007 and March 2012, we collected 374 blood samples from consecutive patients registered in the TAILOR trial. Four SNPs (rs11615, rs3212986, rs17655, rs1047768) were genotyped using real-time polymerase chain reaction.

RESULTS:

The rs11615 polymorphism was associated with histotype (p = 0.0123). No other correlations were found with clinical variables or with EGFR or KRAS mutational status. None of the SNPs had any impact on overall survival or progression-free survival.

CONCLUSIONS:

The findings suggest that the investigated SNPs do not make any significant contribution to the outcome of NSCLC.

• Authors: Eliana Rulli, Mirko Marabese, Sheila Piva, Lucia Bonomi, Elisa Caiola, Monica Ganzinelli
• Journal: Tumori (Tumori) Vol. 102 Issue 4 Pg. 367-75 (Aug 03 2016) ISSN: 2038-2529 [Electronic] United States
• PMID: 27396427 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Biomarkers, Tumor
• Platinum

Topics

• Adult
• Aged
• Alleles
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor
• Carcinoma, Non-Small-Cell Lung (drug therapy, genetics, mortality)
• DNA Repair (genetics)
• Female
• Gene Frequency
• Genes, erbB-1
• Genes, ras
• Genetic Predisposition to Disease
• Genotype
• Humans
• Kaplan-Meier Estimate
• Lung Neoplasms (drug therapy, genetics, mortality)
• Male
• Middle Aged
• Mutation
• Neoplasm Staging
• Platinum (administration & dosage)
• Polymorphism, Single Nucleotide
• Prognosis
• Risk Factors