Werner Syndrome Helicase

A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.

Also Known As:

RECQ3 Protein; RECQL2 Protein; Werner Syndrome ATP-Dependent Helicase; Werner Syndrome RecQ-Like Helicase; Helicase, Werner Syndrome; Werner Syndrome ATP Dependent Helicase; Werner Syndrome RecQ Like Helicase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Deoxyribonucleases: 1259
        Exodeoxyribonucleases: 2
        Werner Syndrome Helicase: 16
      - Exonucleases: 476
        Exodeoxyribonucleases: 2
        Werner Syndrome Helicase: 16
    - Acid Anhydride Hydrolases
      - Adenosine Triphosphatases: 8623
        DNA Helicases: 627
        RecQ Helicases: 389
        Werner Syndrome Helicase: 16
  - Isomerases: 463
    - DNA Helicases: 627
      - RecQ Helicases: 389
        Werner Syndrome Helicase: 16
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Poly-ADP-Ribose Binding Proteins
      - Werner Syndrome Helicase: 16
  - Nuclear Proteins: 2678
    - Poly-ADP-Ribose Binding Proteins
      - Werner Syndrome Helicase: 16

rat WRN protein

Bio-Agent Context: Research Results