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1,3-dodecylpyridinium bromide

synthetic antineoplastic analog of natural cpd from the marine sponge Reniera sarai; structure in first source

Also Known As:

APS12-2

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Pyridinium Compounds: 5
      - 1,3-dodecylpyridinium bromide: 2

Experts

1.	Frangež, Robert: 2 articles (03/2013 - 08/2011)
2.	Grandič, Marjana: 2 articles (03/2013 - 08/2011)
3.	Sepčić, Kristina: 2 articles (03/2013 - 08/2011)
4.	Bajuk, Blanka Premrov: 1 article (03/2013)
5.	Košorok, Marinka Drobnič: 1 article (03/2013)
6.	Juntes, Polona: 1 article (08/2011)
7.	Turk, Tom: 1 article (08/2011)

Related Diseases

1.	Hyperkalemia 03/01/2013 - "Our data show for the first time that APS12-2 induces concentration-dependent contraction of coronary ring preparations, which may contribute to the cardiotoxic effects of APS12-2, in addition to hyperkalemia." 08/15/2011 - "Hyperkalemia probably plays an important role in APS12-2 cardiotoxicity since no evident changes in histopathology of the heart were found. "
2.	Cardiotoxicity 08/15/2011 - "Hyperkalemia probably plays an important role in APS12-2 cardiotoxicity since no evident changes in histopathology of the heart were found. "
3.	Ventricular Premature Complexes (Premature Ventricular Contraction) 08/15/2011 - "Administration of APS12-2 at a dose of 8mg/kg caused a progressive reduction of arterial blood pressure to a mid-circulatory value, accompanied by bradycardia, myocardial ischemia, ventricular extrasystoles, and second degree atrio-ventricular block. "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 08/15/2011 - "Administration of APS12-2 at a dose of 8mg/kg caused a progressive reduction of arterial blood pressure to a mid-circulatory value, accompanied by bradycardia, myocardial ischemia, ventricular extrasystoles, and second degree atrio-ventricular block. "
5.	Bradycardia 08/15/2011 - "Administration of APS12-2 at a dose of 8mg/kg caused a progressive reduction of arterial blood pressure to a mid-circulatory value, accompanied by bradycardia, myocardial ischemia, ventricular extrasystoles, and second degree atrio-ventricular block. "

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