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sparstolonin B

selectively blocks TLR2- and TLR4-mediated inflammatory signaling; isolated from a Chinese herb, Spaganium stoloniferum; structure in first source

Also Known As:

SsnB cpd

Networked: 25 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - sparstolonin B: 25

Experts

1.	Fan, Daping: 9 articles (12/2018 - 01/2013)
2.	Liang, Qiaoli: 5 articles (06/2018 - 01/2013)
3.	Nagarkatti, Prakash: 4 articles (08/2020 - 07/2013)
4.	Chatterjee, Saurabh: 3 articles (08/2020 - 01/2016)
5.	Nagarkatti, Mitzi: 3 articles (08/2020 - 01/2016)
6.	Kimono, Diana: 2 articles (08/2020 - 12/2018)
7.	Sarkar, Sutapa: 2 articles (08/2020 - 12/2018)
8.	Chandrashekaran, Varun: 2 articles (12/2018 - 01/2016)
9.	Dattaroy, Diptadip: 2 articles (12/2018 - 01/2016)
10.	Diehl, Anna Mae: 2 articles (12/2018 - 01/2016)

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 10/01/2015 - "Protective effects of Sparstolonin B, a selective TLR2 and TLR4 antagonist, on mouse endotoxin shock."
2.	Inflammation (Inflammations) 01/01/2016 - "The present study used sparstolonin B (SsnB), a novel TLR4 antagonist derived from the Chinese herb Sparganium stoloniferum, as a possible drug to mitigate early inflammation in NASH. " 08/08/2020 - "TLR Antagonism by Sparstolonin B Alters Microbial Signature and Modulates Gastrointestinal and Neuronal Inflammation in Gulf War Illness Preclinical Model." 01/01/2018 - "The present results suggested that sparstolonin B may attenuate SCI‑induced inflammation and apoptosis in rats by modulating the TLR4/MyD88/NF‑κB signaling pathway." 01/01/2018 - "Sparstolonin B attenuates spinal cord injury‑induced inflammation in rats by modulating TLR4‑trafficking." 10/01/2014 - "The selective TLR2/4 antagonist, Sparstolonin B, can substantially protect LV myocardium via its ability to inhibit injury resulting from hypoxic myocardial-generated inflammation. "
3.	Intervertebral Disc Degeneration 01/01/2018 - "Therefore, the present study aimed to investigate the protective effect of Sparstolonin B in preventing lumbar intervertebral disc degeneration, and explored its potential mechanism in rats. " 01/01/2018 - "Firstly, Sparstolonin B effectively reduced the histological score of disc degeneration and increased endplate porosity of L2 superior endplates in a lumbar IVDD rat model. " 01/01/2018 - "Sparstolonin B prevents lumbar intervertebral disc degeneration through toll like receptor 4, NADPH oxidase activation and the protein kinase B signaling pathway."
4.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2018 - "The present study used a spinal cord injury (SCI) model to evaluate whether sparstolonin B was able to prevent SCI, and to investigate the underlying signaling mechanism. "
5.	Adenocarcinoma 01/01/2022 - "This study aimed to investigate Sparstolonin B's potential antitumor effect on pancreatic adenocarcinoma. " 01/01/2022 - "Sparstolonin B inhibits pancreatic adenocarcinoma through the NF-κB signaling pathway."

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	Phytochemicals
3.	NADPH Oxidases (NAD(P)H oxidase)
4.	Myeloid Differentiation Factor 88
5.	Toll-Like Receptor 4
6.	Toll-Like Receptors (Toll-Like Receptor)
7.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	Transforming Growth Factor beta (TGF-beta)
10.	Cytokines

Related Therapies and Procedures

1.	Electroacupuncture
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)