cholan-2,3,24-tryl-2,3,24-trisulfate

an anti-inflammatory agent and pregnane X receptor agonist isolated from the marine sponge Theonella swinhoei; structure in first source

Also Known As:

5alpha-cholan-2beta,3alpha,24-tryl-2,3,24-sodium trisulfate; solomonsterol A

Networked: 2 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholanes
      - cholan-2,3,24-tryl-2,3,24-trisulfate: 2
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfur Acids
    - Sulfuric Acids: 4
      - Sulfuric Acid Esters: 2
        cholan-2,3,24-tryl-2,3,24-trisulfate: 2

Experts

1.	D'Amore, Claudio: 2 articles (12/2013 - 07/2011)
2.	D'Auria, Maria Valeria: 2 articles (12/2013 - 07/2011)
3.	Fiorucci, Stefano: 2 articles (12/2013 - 07/2011)
4.	Mencarelli, Andrea: 2 articles (12/2013 - 07/2011)
5.	Renga, Barbara: 2 articles (12/2013 - 07/2011)
6.	Sepe, Valentina: 2 articles (12/2013 - 07/2011)
7.	Zampella, Angela: 2 articles (12/2013 - 07/2011)
8.	Carino, Adriana: 1 article (12/2013)
9.	Cipriani, Sabrina: 1 article (12/2013)
10.	Distrutti, Eleonora: 1 article (12/2013)

Related Diseases

1.	Inflammation (Inflammations) 07/14/2011 - "In summary, solomonsterol A is a marine PXR agonist that holds promise in the treatment of inflammation-driven immune dysfunction in clinical settings." 12/24/2013 - "In the present study we provide evidence that solomonsterol A, a selective pregnane X receptor (PXR) agonist isolated from the marine sponge Theonella swinhoei, exerts anti-inflammatory activity and attenuates systemic inflammation and immune dysfunction in a mouse model of rheumatoid arthritis. " 12/24/2013 - "Solomonsterol A rescued mice from systemic inflammation were assessed by measuring arthritis score, CRP and cytokines in the blood. " 12/24/2013 - "Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis."
2.	Arthritis (Polyarthritis) 12/24/2013 - "Solomonsterol A rescued mice from systemic inflammation were assessed by measuring arthritis score, CRP and cytokines in the blood. " 12/24/2013 - "Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis." 12/24/2013 - "Solomonsterol A was effective in protecting against the development of arthritis induced by injecting transgenic mice harboring a humanized PXR, with anti-collagen antibodies (CAIA) with beneficial effects on joint histopathology and local inflammatory response reducing the expression of inflammatory markers (TNFα, IFNγ and IL-17 and chemokines MIP1α and RANTES) in draining lymph nodes. "
3.	Rheumatoid Arthritis 12/24/2013 - "In the present study we provide evidence that solomonsterol A, a selective pregnane X receptor (PXR) agonist isolated from the marine sponge Theonella swinhoei, exerts anti-inflammatory activity and attenuates systemic inflammation and immune dysfunction in a mouse model of rheumatoid arthritis. "
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 07/14/2011 - "In addition, we have provided the first evidence that solomonsterol A might act by triggering the expression of TGFβ and IL-10, potent counter-regulatory cytokines in inflammatory bowel diseases (IBD). "
5.	Colitis 07/14/2011 - "In this article, we describe the first total synthesis of solomonsterol A and its in vivo characterization in animal models of colitis. " 07/14/2011 - "Using transgenic mice expressing the human PXR, we found that administration of synthetic solomonsterol A effectively protects against development of clinical signs and symptoms of colitis and reduced the generation of TNFα, a signature cytokine for this disorder. "

Related Drugs and Biologics

1.	Chemokine CCL5
2.	Chemokines
3.	Collagen
4.	Antibodies
5.	Pregnane X Receptor
6.	Cytokines
7.	Interleukin-10 (Interleukin 10)