12,13- dihydro- N- methyl- 6,11,13- trioxo- 5H- benzo(4,5)cyclohepta(1,2- b)naphthalen- 5,12- imine

01/01/2015 - "Clinical studies suggest that TU-100 is beneficial for postoperative complications, especially ileus and abdominal bloating. "

10/01/2017 - "TU-100 co-treatment significantly reversed diarrhea, BT, and the expression of TLR2, IL-6, TNF-α, IL-1β and caspase-3, and improved the expression of occludin, claudin-4 and ZO-1. "

01/01/2013 - "Our current aims were to examine whether TU-100 ameliorates a type-2 model colitis that histologically resembles UC and identify the active ingredients. "
01/01/2013 - "TU-100 exerted a protective effect in OXN-induced type-2 model colitis, indicating that TU-100 may be a beneficial agent for treatment of UC. "
01/01/2013 - "TU-100 was administered orally to mice with oxazolone- (OXN-) induced type-2 model colitis. "
01/01/2013 - "Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells."

01/31/2016 - "Our aim was to study the effects of TU-100 on rectal compliance and sensation in patients with irritable bowel syndrome (IBS). "
06/01/2010 - "Further randomized controlled trials in patients with functional constipation or irritable bowel syndrome with constipation are warranted to evaluate the clinical efficacy of TU-100 in these disorders."

12/08/2020 - "In this study, we report new findings as the direct and indirect inhibitory effects of TU-100 on cancer cell growth through the suppression of HSC activation. "
05/01/2023 - "TU-100 may alleviate the progression of cancer by regulating the M2 polarization of macrophages within the TME, suggesting a viable therapeutic approach."
05/01/2023 - "TU-100 (Daikenchuto) is a commonly prescribed Japanese herbal medicine that has shown anti-cancer effects by regulating cancer-associated fibroblasts (CAFs) in the TME. "
01/01/2023 - "Tumor diameter was significantly smaller in the TU-100 group compared with that in the control group (P?<?0.05). "
01/04/2021 - "Our data showed that TU-100 can affect the intestinal environment; however, it does not contribute in tumor progression or inhibition in our setting."