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acycloguanosyl 5'-thymidyltriphosphate

an antineoplastic agent; structure in first source

Also Known As:

ACV-TP-T

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Galli, Andrea: 3 articles (09/2015 - 02/2011)
2.	Calamante, Massimo: 2 articles (11/2014 - 02/2011)
3.	Ceni, Elisabetta: 2 articles (11/2014 - 02/2011)
4.	Luchinat, Claudio: 2 articles (11/2014 - 02/2011)
5.	Polvani, Simone: 2 articles (11/2014 - 02/2011)
6.	Quattrone, Alessandro: 2 articles (11/2014 - 02/2011)
7.	Webb, Thomas E: 1 article (09/2015)
8.	Marroncini, Giada: 1 article (11/2014)
9.	Mello, Tommaso: 1 article (11/2014)
10.	Peired, Anna Julie: 1 article (11/2014)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 02/01/2011 - "We evaluated proliferation and apoptosis of human pancreatic cancer cells (PANC-1, MiaPaca2, BxPc3, PL45, and Su.86.86) incubated with ACV-TP-T. " 02/01/2011 - "The prodrug of ACV-TP-T was actively metabolized inside pancreatic cancer cells into the activated form of acyclovir; proliferation was reduced, apoptosis was increased, and the cell cycle was altered in pancreatic cancer incubated with ACV-TP-T, compared with controls. " 02/01/2011 - "ACV-TP-T, a thymidine analogue that is metabolized by telomerase and releases the active form of acyclovir, reduces proliferation and induces apoptosis of human pancreatic cancer cell lines in vitro and pancreatic xenograft tumors in mice."
2.	Neoplasms (Cancer) 02/01/2011 - "Administration of ACV-TP-T to mice reduced growth, increased apoptosis, and reduced proliferation and vascularization of pancreatic xenograft tumors. " 02/01/2011 - "Acycloguanosyl 5'-thymidyltriphosphate, a thymidine analogue prodrug activated by telomerase, reduces pancreatic tumor growth in mice." 02/01/2011 - "ACV-TP-T, a thymidine analogue that is metabolized by telomerase and releases the active form of acyclovir, reduces proliferation and induces apoptosis of human pancreatic cancer cell lines in vitro and pancreatic xenograft tumors in mice."
3.	Liver Neoplasms (Liver Cancer) 11/01/2014 - "Second, we evaluated proliferation and apoptosis in murine (Hepa1-6) and human (Hep3B, HuH7, HepG2) hepatic cancer cells treated with ACV-TP-T. " 11/01/2014 - "ACV-TP-T is activated by telomerase in HCC cells and releases active acyclovir that reduces proliferation and induces apoptosis in human and murine liver cancer cells. "
4.	Hepatocellular Carcinoma (Hepatoma) 09/01/2015 - "Hepatocellular carcinoma cells that develop resistance to the telomerase-activated prodrug ACV-TP-T may undergo spontaneous apoptosis."

Related Drugs and Biologics

1.	Telomerase (Telomerase Reverse Transcriptase)
2.	Prodrugs
3.	Acyclovir (Aciclovir)
4.	Thymidine