Absence of Tibia
A rare autosomal recessive anomaly characterized by deficiency of the tibia with relatively intact FIBULA. It may present as an isolated anomaly or be associated with a variety of skeletal and extraskeletal malformations. Tibial hemimelia may also constitute a part of a more complicated malformation complex or syndrome, such as the Gollop-Wolfgang complex (OMIM: 228250) and triphalangeal thumb-polysyndactyly syndrome (OMIM: 174500). OMIM: 275220
Also Known As:
Bilateral absence of the tibia; Tibia, absence of; Tibial hemimelia
Networked: 21
relevant articles (1 outcomes,
2 trials/studies)
Relationship Network
Disease Context: Research Results
Related Diseases
Experts
1. | Colle, Pierre-Emmanuel:
2 articles
(02/2010 - 06/2008)
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2. | Saragaglia, Dominique:
2 articles
(02/2010 - 06/2008)
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3. | Albright, Patrick:
1 article
(04/2019)
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4. | Bovid, Karen:
1 article
(04/2019)
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5. | Habeck, Jason:
1 article
(04/2019)
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6. | Veenstra, Joshua:
1 article
(04/2019)
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7. | Yadav, Surender Singh:
1 article
(03/2019)
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8. | Deng, Kai:
1 article
(01/2019)
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9. | Wang, Guorong:
1 article
(01/2019)
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10. | Yu, Guorong:
1 article
(01/2019)
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Drugs and Biologics
Drugs and Important Biological Agents (IBA) related to Absence of Tibia:
1. | TeratogensIBA
01/01/1989
- " In a number of experiments it was proved, however, that these hybrids (LEW/BN, +/lx) had an increased sensitivity to the induction of limb malformations (polydactyly, tibial hemimelia, oligodactyly) by various teratogens. " 02/01/1975
- " The incidence and degree of expression of the effects (polydactyly, ectrodactyly, radial hemimelia, tibial hemimelia, pelvic girdle shifts, deformed caudal vertebrae) varied according to the teratogen and dose level. "
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2. | DinoprostIBA
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3. | Methotrexate (Mexate)FDA LinkGeneric
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4. | DNA Transposable Elements (Element, IS)IBA
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5. | Amantadine (Aman)FDA LinkGeneric
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6. | OsseusIBA
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Therapies and Procedures