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fasentin

chemical sensitizer to death receptor stimuli FAS; structure in first source

Also Known As:

N-(4-chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - Anilides: 22
      - fasentin: 5
- Amides: 2428
  - Anilides: 22
    - fasentin: 5

Experts

1.	Martínez-Poveda, Beatriz: 1 article (01/2020)
2.	Marí-Beffa, Manuel: 1 article (01/2020)
3.	Medina, Miguel Ángel: 1 article (01/2020)
4.	Ocaña, Mª Carmen: 1 article (01/2020)
5.	Quesada, Ana R: 1 article (01/2020)
6.	Airala, Subra: 1 article (09/2019)
7.	Asuthkar, Swapna: 1 article (09/2019)
8.	Guda, Maheedhara R: 1 article (09/2019)
9.	Labak, Collin M: 1 article (09/2019)
10.	Omar, Sara Ibrahim: 1 article (09/2019)

Related Diseases

1.	Non-ST Elevated Myocardial Infarction 12/13/2022 - "In NSTEMI patients, treatment with Shikonin and Fasentin, which inhibits PKM2 enzyme activity and GLUT-1 mediated glucose internalization, respectively, led to a significant reduction in GLUT-1 expression along with the downregulation of pro-inflammatory cytokine expression. "
2.	Neoplasms (Cancer) 01/01/2020 - "Taken together, our results show a novel biological activity of fasentin, which could be evaluated for its utility in cancer and other angiogenesis-dependent diseases." 01/01/2020 - "The synthetic compound fasentin has been described as a modulator of GLUT-1 and GLUT-4 transporters, thus inhibiting glucose uptake in some cancer cells. " 02/23/2023 - "(2) Methods: the proliferation and survival rate of tumor cells was significantly affected by the GLUT-inhibitors fasentin and WZB1127, as well as by the NAMPT inhibitors GMX1778 and STF-31. " 10/01/2018 - "Here, we aimed to assess the impact of the glucose transporter (GLUT) inhibitors fasentin and WZB117, and the nicotinamide phosphoribosyltransferase (NAMPT) inhibitors GMX1778 and STF-31 on tumor cell proliferation and survival, as well as on glucose uptake. " 10/01/2018 - "Tumor-derived A172 (glioblastoma), BHY (oral squamous cell carcinoma), HeLa (cervix adenocarcinoma), HN (head neck cancer), HT-29 (colon carcinoma) and MG-63 (osteosarcoma) cells were treated with fasentin, WZB117, GMX1778 and STF-31. "
3.	Glioblastoma (Glioblastoma Multiforme) 09/05/2019 - "Using both mass spectrometry performed on hGBM (human glioblastoma patient specimen) and in silico modeling, we show that GLUT1 interacts with TUBB4, and more accurately demonstrates GLUT1's binding with fasentin. " 10/01/2018 - "Tumor-derived A172 (glioblastoma), BHY (oral squamous cell carcinoma), HeLa (cervix adenocarcinoma), HN (head neck cancer), HT-29 (colon carcinoma) and MG-63 (osteosarcoma) cells were treated with fasentin, WZB117, GMX1778 and STF-31. "
4.	Osteosarcoma (Osteogenic Sarcoma) 10/01/2018 - "Tumor-derived A172 (glioblastoma), BHY (oral squamous cell carcinoma), HeLa (cervix adenocarcinoma), HN (head neck cancer), HT-29 (colon carcinoma) and MG-63 (osteosarcoma) cells were treated with fasentin, WZB117, GMX1778 and STF-31. "
5.	Head and Neck Neoplasms (Head and Neck Cancer) 10/01/2018 - "Tumor-derived A172 (glioblastoma), BHY (oral squamous cell carcinoma), HeLa (cervix adenocarcinoma), HN (head neck cancer), HT-29 (colon carcinoma) and MG-63 (osteosarcoma) cells were treated with fasentin, WZB117, GMX1778 and STF-31. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Cytokines
3.	Enzymes
4.	shikonin
5.	N- (6- chlorophenoxyhexyl)- N''- cyano- N''- 4- pyridylguanidine (CHS 828)
6.	STF-31
7.	Nicotinamide Phosphoribosyltransferase
8.	Facilitative Glucose Transport Proteins (Glucose Transporter)
9.	WZB117