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L-873724

a selective inhibitor of cathepsin K; structure in first source

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        L-873724: 2

Experts

1.	Duong, Le T: 1 article (12/2013)
2.	Kimmel, Donald B: 1 article (12/2013)
3.	Levesque, Sonia: 1 article (12/2013)
4.	Oballa, Renata M: 1 article (12/2013)
5.	Pennypacker, Brenda L: 1 article (12/2013)
6.	Black, W Cameron: 1 article (10/2006)
7.	Percival, M David: 1 article (10/2006)

Related Diseases

1.	Bone Resorption 12/09/2013 - "In this study, the efficacy of the selective inhibitors L-833905, L-006235, L-873724, and L-1037536 (ODN) of human CatK in the rapidly growing rabbit 'Schenk' model (age seven weeks) was compared to vehicle, using the bisphosphonate, alendronate (ALN), as a positive control, to assess inhibition of bone resorption. "
2.	Osteoporosis 10/01/2006 - "L-873724 exhibits excellent pharmacokinetics and is orally active in a monkey model of osteoporosis at 3 mg kg(-1) q.d."

Related Drugs and Biologics

1.	Alendronate (Alendronate Sodium)
2.	Diphosphonates (Bisphosphonates)
3.	odanacatib
4.	CRA 013783
5.	N- (cyanomethyl)- 4- methyl- 2- (4'- (1- piperazinyl)(1,1'- biphenyl)- 3- yl)pentanamide