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NOX-B11-3
a ghrelin blocking agent
Also Known As:
spiegelmer NOX-B11-3
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleotides: 15763
Polynucleotides: 218
Oligonucleotides: 5145
Nucleotide Aptamers: 598
NOX-B11-3: 1
Experts
1.
Becskei, C
: 1 article (01/2008)
2.
Bilik, K U
: 1 article (01/2008)
3.
Jarosch, F
: 1 article (01/2008)
4.
Klussmann, S
: 1 article (01/2008)
5.
Lutz, T A
: 1 article (01/2008)
6.
Riediger, T
: 1 article (01/2008)
Related Diseases
1.
AIDS-Related Complex (ARC)
01/01/2008 - "
However, when injected at the beginning of a 14-h fasting period, the same dose of NOX-B11-3 had no effect on the c-Fos expression in the Arc of mice.
"
01/01/2008 - "
These results demonstrate that NOX-B11-3 is a long-acting compound, which effectively blocks the effect of exogenous ghrelin on neuronal activity in the Arc under in vitro and in vivo conditions.
"
01/01/2008 - "
Furthermore, NOX-B11-3 (15 mg/kg i.p.) potently suppressed ghrelin-induced (25 microg/kg s.c., 12 h after SPM injection) c-Fos expression in the Arc.
"
01/01/2008 - "
In electrophysiological in vitro single cell recordings, NOX-B11-3 effectively blocked the excitatory effect of ghrelin in the medial Arc (ArcM) of rats whereas the biologically inactive control SPM had no effect.
"
Related Drugs and Biologics
1.
Ghrelin