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perforin 2

was indexed under perforin[nm]

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - perforin 2: 6

Experts

1.	Podack, Eckhard R: 3 articles (04/2017 - 12/2013)
2.	McCormack, Ryan: 2 articles (04/2016 - 12/2013)
3.	Baker, Jennifer L: 1 article (01/2020)
4.	Butte, Manish J: 1 article (01/2020)
5.	Jiang, Shirley Y: 1 article (01/2020)
6.	Lee, Hane: 1 article (01/2020)
7.	Merselis, Leidy C: 1 article (01/2020)
8.	Munson, George P: 1 article (01/2020)
9.	Nelson, Stanley F: 1 article (01/2020)
10.	Prabaker, Kavitha K: 1 article (01/2020)

Related Diseases

1.	Infections 04/20/2017 - "MPEG1/perforin-2 mutations in human pulmonary nontuberculous mycobacterial infections." 01/01/2015 - "The combined results of these two in vivo infection models support the anti-bacterial function of the MPEG1/perforin-2 family and indicate that the intricate cross-regulation of the two mpeg1 copies aids the zebrafish host in combatting infection of various pathogens." 01/01/2020 - "MPEG1/Perforin-2 Haploinsufficiency Associated Polymicrobial Skin Infections and Considerations for Interferon-γ Therapy."
2.	Neoplasms (Cancer) 12/01/2013 - "The highly efficient mechanism of anti-microbial defense by a combined physical and chemical strategy using pore-forming MACPF-proteins has been retargeted during evolution of vertebrates and mammals for three purposes: (1) to kill extracellular bacteria C9/polyC9 evolved in conjunction with complement, (2) to kill virus infected and cancer cells perforin-1/polyperforin-1 CTL evolved targeted by NK and CTL, and (3) to kill intracellular bacteria transmembrane perforin-2/putative polyperforin-2 evolved targeted by phagocytic and nonphagocytic cells. "
3.	Acute Disease 04/01/2016 - "monocytogenes in Perforin-2(-/-)mice leads to a rapid appearance of acute disease symptoms. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/2015 - "The combined results of these two in vivo infection models support the anti-bacterial function of the MPEG1/perforin-2 family and indicate that the intricate cross-regulation of the two mpeg1 copies aids the zebrafish host in combatting infection of various pathogens."
5.	Missed Abortion 07/01/1997 - "In the missed abortion group, we found: 1) a relative decrease in the frequency of both CD4+P+ cells and CD56+P+ cells as well as the mean fluorescence intensity for perforin; 2) a relative increase of CD16+P+ PBL cells; and 3) a relative increase of CD4+ cells in PBL compared with anembryonic pregnancy and normal pregnancy. "

Related Drugs and Biologics

1.	Perforin
2.	Proteins (Proteins, Gene)
3.	Interferons
4.	Complement C2 (Complement Component 2)
5.	polyperforin

Related Therapies and Procedures

1.	Therapeutics