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B-9958

a dual-function peptide that combines aminopeptidase N inhibition and kinin B1 receptor antagonism

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Adam, Albert: 1 article (04/2006)
2.	Fortin, Jean-Philippe: 1 article (04/2006)
3.	Gera, Lajos: 1 article (04/2006)
4.	Marceau, François: 1 article (04/2006)
5.	Stewart, John M: 1 article (04/2006)
6.	Bachvarov, D R: 1 article (11/2000)
7.	Bouthillier, J: 1 article (11/2000)
8.	Gera, L: 1 article (11/2000)
9.	Houle, S: 1 article (11/2000)
10.	Larrivée, J F: 1 article (11/2000)

Related Diseases

1.

11/01/2000 - "B-9958 (Lys-[Hyp(3), CpG(5), D-Tic(7), CpG(8)]des-Arg(9)-BK) was also surmountable (pA(2) 8.5). "
04/01/2006 - "In this study, we found that the high-affinity antagonist B-9958 (Lys-Lys-[Hyp(3), CpG(5), D-Tic(7), CpG(8)]des-Arg(9)-BK; des-Arg(9)-BK, des-arginine(9)-bradykinin) is an aminopeptidase N substrate based on its capacity to compete for the hydrolysis of the chromogenic substrate L-Ala-p-nitroanilide by membranes isolated from human or rabbit arterial smooth muscle cells, its inactivation in the presence of these membranes (radioreceptor assay) and on its intense potentiation by the aminopeptidase N inhibitor amastatin in the rabbit aorta contractility assay (gain of 0.84 units in the pA(2) scale). "

Related Drugs and Biologics

1.	CD13 Antigens (Alanine Aminopeptidase)
2.	Chromogenic Compounds
3.	Bradykinin
4.	Arginine (L-Arginine)
5.	lysyllysine (Lys-Lys)
6.	amastatin