pyrrocidine A

an antifungal antibiotic isolated from Acremonium zeae; structure in first souce

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Ansari, Mohabbat: 1 article (01/2021)
2.	Ebrahimi, Kosar Sadat: 1 article (01/2021)
3.	Ebrahimi, Zohre: 1 article (01/2021)
4.	Hosseyni Moghaddam, Mahdieh S: 1 article (01/2021)
5.	Moradi, Sajad: 1 article (01/2021)
6.	Salehi, Zohre: 1 article (01/2021)
7.	Shahlaei, Mohsen: 1 article (01/2021)
8.	Höfert, Simon-Patrick: 1 article (07/2018)
9.	Janiak, Christoph: 1 article (07/2018)
10.	Kalscheuer, Rainer: 1 article (07/2018)

1.	Acute Promyelocytic Leukemia 03/01/2016 - "We have previously reported that pyrrocidine A shows potent cytotoxicity against human acute promyelocytic leukemia HL60 cells, and the activity is 70-fold higher than that of pyrrocidine B which is the analog lacking the α,β-unsaturated carbonyl group. "
2.	Ovarian Neoplasms (Ovarian Cancer) 07/01/2018 - "Pyrrocidine A (12) exhibited potent cytotoxicity against the human ovarian cancer cell line A2780 with an IC50 value of 1.7 μM. "
3.	Neoplasms (Cancer) 03/01/2016 - "JFCR39 human cancer cells panel indicated that the mechanism of action of pyrrocidine A is different from other clinical anticancer drugs, and this compound broadly inhibited the growth of various cancer cell lines. "
4.	COVID-19 01/01/2021 - "In conclusion, it is recommended to further evaluate the compounds 18-methoxy cytochalasin J and pyrrocidine A in the laboratory as good candidates for inhibiting COVID-19."