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Jelleine I

an antimicrobial peptide from the Royal Jelly of honeybees (Apis mellifera)

Also Known As:

PFKLSLHL-NH(2)

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Jelleine I: 4

Experts

1.	He, Yuhang: 1 article (03/2021)
2.	Jia, Fengjing: 1 article (03/2021)
3.	Liu, Kexin: 1 article (03/2021)
4.	Lu, Yaqi: 1 article (03/2021)
5.	Wang, Jiayi: 1 article (03/2021)
6.	Wang, Kairong: 1 article (03/2021)
7.	Yan, Wenjin: 1 article (03/2021)
8.	Zhang, Lishi: 1 article (03/2021)
9.	Zhou, Jingjing: 1 article (03/2021)
10.	Arcisio-Miranda, Manoel: 1 article (05/2020)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/11/2023 - "Optimized Antimicrobial Peptide Jelleine-I Derivative Br-J-I Inhibits Fusobacterium Nucleatum to Suppress Colorectal Cancer Progression."
2.	Peritonitis 03/01/2021 - "In addition, the result of in vivo antimicrobial activity experiment showed that Jelleine-I performed a good therapeutic effect toward the mice with Escherichia coli infected peritonitis. "
3.	Melanoma (Melanoma, Malignant) 05/01/2020 - "Aiming a deeper understanding, we chose the octapeptide Jelleine-I (JI) for its selective and low toxicity profile, designed small modifications combining the substitutions of Phe by Trp and Lys/His by Arg and tested the antimicrobial and anticancer activity on melanoma cells. "
4.	Hemolysis 02/16/2023 - "Furthermore, Jelleine-I increased the G1 to S phase transition in mammalian cells from cells cycle analysis, and cytotoxicity assay results indicated that it promoted cell proliferation without hemolysis or cytotoxicity. "
5.	Bacterial Infections (Bacterial Infection) 02/16/2023 - "Results of immunomodulation in Galleria mellonella revealed that Jelleine-I increased host hemocyte counts, upregulated host AMP gene (Gloverin and Cecropin D) expression, and inhibited proinfammatory cytokine (tumor necrosis factor α and interleukin 6) production induced by bacterial infection. "

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Cytokines
3.	Interleukin-6 (Interleukin 6)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Adenosine Monophosphate (AMP)
6.	Antimicrobial Peptides
7.	gloverin
8.	Hyalophora cecropia cecropin D protein

Related Therapies and Procedures

1.	Immunomodulation