Peroxisomal Multifunctional Protein-2

A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.

Also Known As:

17-beta-Hydroxysteroid Dehydrogenase 4; 3- alpha,7- alpha,12- alpha- Trihydroxy- 5- beta- Cholest- 24- enoyl- CoA Hydratase; Peroxisomal Multifunctional Enzyme Type 2; 17 beta Hydroxysteroid Dehydrogenase 4; 4, 17-beta-Hydroxysteroid Dehydrogenase; Dehydrogenase 4, 17-beta-Hydroxysteroid; Multifunctional Protein-2, Peroxisomal; Peroxisomal Multifunctional Protein 2

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - Hydroxysteroid Dehydrogenases: 313
        17-Hydroxysteroid Dehydrogenases: 4
        Peroxisomal Multifunctional Protein-2: 4
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        3-Hydroxyacyl CoA Dehydrogenases
        Peroxisomal Multifunctional Protein-2: 4
  - Lyases: 637
    - Carbon-Oxygen Lyases
      - Hydro-Lyases: 266
        Enoyl-CoA Hydratase 2: 1
        Peroxisomal Multifunctional Protein-2: 4
  - Multifunctional Enzymes: 108
    - Peroxisomal Multifunctional Protein-2: 4

rat Hsd17b4 protein

Bio-Agent Context: Research Results