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S 32504

a naphtoxazine analog with antiparkinsonian activity; acts on dopamine receptor D2/D3 heterodimers

Also Known As:

S-32504; S32504

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - S 32504: 4

Experts

1.	Millan, Mark J: 4 articles (12/2006 - 06/2004)
2.	Joyce, Jeffrey N: 2 articles (11/2004 - 06/2004)
3.	Brocco, Mauricette: 2 articles (06/2004 - 06/2004)
4.	Peglion, Jean-Louis: 2 articles (06/2004 - 06/2004)
5.	Brotchie, Jonathan M: 1 article (12/2006)
6.	Crossman, Alan R: 1 article (12/2006)
7.	Hill, Michael P: 1 article (12/2006)
8.	McGuire, Steven G: 1 article (12/2006)
9.	Ravenscroft, Paula: 1 article (12/2006)
10.	Rochat, Catherine: 1 article (12/2006)

Related Diseases

1.	Dyskinesias (Dyskinesia) 12/01/2006 - "However, there is considerable interest in D3/D2 receptor agonists such as the novel agent S32504, since they exert antiparkinsonian properties in the absence of dyskinesia. " 06/01/2004 - "Furthermore, S32504 dose-dependently reversed bradykinesia and improved posture in "L-DOPA-primed" animals, whereas eliciting less pronounced dyskinesia than l-DOPA. "
2.	Hypokinesia (Bradykinesia) 06/01/2004 - "Furthermore, S32504 dose-dependently reversed bradykinesia and improved posture in "L-DOPA-primed" animals, whereas eliciting less pronounced dyskinesia than l-DOPA. "
3.	Anhedonia 06/01/2004 - "Furthermore, in a chronic mild stress model of anhedonia, S32504 (0.16-2.5 mg/kg) rapidly restored the suppression of sucrose consumption. "
4.	Neuroblastoma 11/01/2004 - "To test if the D(3) receptor preferring agonists S32504 and pramipexole act through D(2) or D(3) receptors and via brain-derived neurotrophic factor (BDNF)-dependent pathways, we utilized a terminally differentiated neuroblastoma SH-SY5Y cell line exhibiting a dopaminergic phenotype. "

Related Drugs and Biologics

1.	Levodopa (L Dopa)
2.	Brain-Derived Neurotrophic Factor (BDNF)
3.	Sucrose (Saccharose)
4.	Pramipexole (Mirapex)