spiggin

an adhesive protein secreted into the urinary bladder for later use in nest building; isolated from Gasterosteus aculeatus, the three-spined stickleback; GenBank AF323732 (alpha-subunit), AF323733 (beta-subunit), and AF323734 (gamma-subunit)

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Katsiadaki, Ioanna: 2 articles (08/2020 - 12/2004)
2.	Fitzgerald, Jennifer A: 1 article (08/2020)
3.	Santos, Eduarda M: 1 article (08/2020)
4.	Trznadel, Maciej: 1 article (08/2020)
5.	Brandt, Ingvar: 1 article (02/2013)
6.	Brunström, Björn: 1 article (02/2013)
7.	Fick, Jerker: 1 article (02/2013)
8.	Svensson, Johan: 1 article (02/2013)
9.	Barber, I: 1 article (09/2011)
10.	Katsiadaki, I: 1 article (09/2011)

Related Diseases

1.	Hypertrophy 12/20/2004 - "Paradoxically, slightly elevated spiggin levels and kidney hypertrophy were observed also in fish treated with high dose E2. " 02/19/2013 - "Androgenic effects were found at LNG concentrations ≥40 ng L(-1) including induction of spiggin transcription, kidney hypertrophy, and suppressed liver vitellogenin transcription. " 12/20/2004 - "The juvenile three-spined stickleback (Gasterosteus aculeatus L.) as a model organism for endocrine disruption II--kidney hypertrophy, vitellogenin and spiggin induction." 05/25/2001 - "In the breeding male the kidney hypertrophies and synthesizes an adhesive protein called "spiggin," which is secreted into the urinary bladder from where it is employed as a structural thread for nest building. " 05/14/2009 - "For both peptide antibodies the quantification range was determined to be between 1 and 80 ng spiggin and determination of renal spiggin levels from immature and mature males displayed a 15-fold increase in total spiggin content of the kidney resulting in a 6-fold increase in male kidney weight due to hypertrophy. "
2.	Infections 09/01/2011 - "However in a second population infection levels were more variable and males with smaller infections recorded 11KT and spiggin titres that overlapped those of non-infected fish; among infected males from this population 11KT and kidney spiggin also both correlated negatively with infection severity. " 09/01/2011 - "In one population infected males harbored heavy infections and showed uniformly reduced 11KT titres and kidney spiggin (nesting glue protein) content compared to non-infected fish. "
3.	Hypoxia (Hypoxemia) 08/01/2020 - "In contrast, for linuron, a strong inhibition of spiggin was observed under 97% AS, but this effect was supressed under reduced air saturation, likely due to interactions between the hypoxia inducible factor and the aryl hydrocarbon receptor (AhR) pathways. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Vitellogenins (Vitellogenin)
3.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
4.	Peptides (Polypeptides)
5.	Linuron
6.	Antibodies
7.	Androgens