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1- O- octadecyl- sn- glycerol- 3- phosphonoformate
a lipid prodrug of foscarnet
Also Known As:
ODG-PFA
Networked:
3
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Acyclic Acids
Acetates: 4994
Phosphonoacetic Acid: 96
Foscarnet: 943
1-O-octadecyl-sn-glycerol-3-phosphonoformate: 3
Alcohols: 595
Sugar Alcohols: 143
Triose Sugar Alcohols: 4
Glyceryl Ethers: 12
Phospholipid Ethers: 36
1-O-octadecyl-sn-glycerol-3-phosphonoformate: 3
Organophosphorus Compounds: 300
Organophosphonates: 424
Phosphonoacetic Acid: 96
Foscarnet: 943
1-O-octadecyl-sn-glycerol-3-phosphonoformate: 3
Ethers: 242
Glyceryl Ethers: 12
Phospholipid Ethers: 36
1-O-octadecyl-sn-glycerol-3-phosphonoformate: 3
Lipids: 114793
Membrane Lipids: 1591
Phospholipids: 11903
Glycerophosphates: 118
Phosphatidic Acids: 358
Glycerophospholipids: 689
Phospholipid Ethers: 36
1-O-octadecyl-sn-glycerol-3-phosphonoformate: 3
Related Diseases
1.
Retinitis
03/01/1999 - "
Intravitreal liposomal ODG-PFA may be expected to be a long acting potent local therapy for CMV retinitis.
"
01/01/1999 - "
Sixty-four pigmented rabbits were used for evaluation of the potency and duration of action of ODG-PFA after intravitreal injection using a herpes simplex virus (HSV)-1 retinitis model.
"
01/01/1999 - "
Treatment of herpes retinitis in an animal model with a sustained delivery antiviral drug, liposomal 1-O-octadecyl-SN-glycerol-3-phosphonoformate.
"
01/01/1999 - "
Liposomal ODG-PFA is a potent long-lasting intravitreal injectable antiviral compound that may be an ideal alternative for treatment of CMV retinitis in patients with acquired immunodeficiency syndrome.
"
06/01/1999 - "
The 50% inhibitory concentration (IC50) for CMV of ODG-PFA was 0.43+/-0.27 microM, and the therapeutic index of ODG-PFA after intravitreal injection was estimated to be 1470:1. Lipid-derivatized foscarnet liposome formulations may be a useful long-acting delivery system for the therapy of CMV retinitis.
"
2.
Acquired Immunodeficiency Syndrome (AIDS)
01/01/1999 - "
Liposomal ODG-PFA is a potent long-lasting intravitreal injectable antiviral compound that may be an ideal alternative for treatment of CMV retinitis in patients with acquired immunodeficiency syndrome.
"
Related Drugs and Biologics
1.
1- O- octadecyl- sn- glycerol- 3- phosphonoformate
2.
Foscarnet
3.
Prodrugs
4.
Lipids
5.
Liposomes (Liposome)
6.
Antiviral Agents (Antivirals)
Related Therapies and Procedures
1.
Injections
2.
Intravitreal Injections
3.
Therapeutics