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arteflene
structure in first source
Also Known As:
Ro 42-1611; Ro-42-1611
Networked:
5
relevant articles (
3
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Free Radicals: 15039
Reactive Oxygen Species: 39360
Artemisinins: 238
arteflene: 5
Hydrocarbons: 1713
Terpenes: 1461
Sesquiterpenes: 1370
Artemisinins: 238
arteflene: 5
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzylidene Compounds: 10
Styrenes: 6
arteflene: 5
Heterocyclic Compounds: 198
Bridged-Ring Heterocyclic Compounds
Heterocyclic Bridged Bicyclo Compounds
arteflene: 5
Inorganic Chemicals: 9
Free Radicals: 15039
Reactive Oxygen Species: 39360
Artemisinins: 238
arteflene: 5
Related Diseases
1.
Malaria
09/01/1994 - "
Ro 42-1611 in the treatment of patients with mild malaria: a clinical trial in Nigeria and Burkina Faso.
"
09/01/1994 - "
An open, non-comparative clinical trial was carried out in Nigeria and Burkina Faso to investigate the safety and efficacy of the novel antimalarial arteflene in patients with mild malaria.
"
09/01/1994 - "
Efficacy of Ro 42-1611 (arteflene) in the treatment of patients with mild malaria: a clinical trial in Cameroon.
"
09/01/1994 - "
The novel antimalarial Ro 42-1611 (arteflene) was evaluated for safety and efficacy in an open, non-comparative study of patients with mild malaria in the south of Cameroon.
"
09/01/1994 - "
Ro 42-1611 (arteflene) is a new synthetic structural analogue of yingzhaosu, a Chinese traditional herbal drug, now under development for treatment of malaria.
"
2.
Fever (Fevers)
09/01/1996 - "
Arteflene cleared fever slightly but not significantly faster than mefloquine and the 50% and 90% parasite clearance times were comparable in both treatment groups.
"
3.
Melanoma (Melanoma, Malignant)
06/01/1995 - "
Ro 42-1611 only slightly suppressed cytoadherence of infected erythrocytes to melanoma cells.
"
06/01/1995 - "
The purpose of this study was to investigate the ability of the antimalarial drug, Ro 42-1611 to block parasite mediated cytokine induction in vitro as well as cytoadherence of infected erythrocytes to melanoma cells in vitro.
"
4.
Falciparum Malaria (Plasmodium falciparum Malaria)
09/01/1996 - "
Arteflene compared with mefloquine for treating Plasmodium falciparum malaria in children.
"
06/01/1995 - "
The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites.
"
Related Drugs and Biologics
1.
arteflene
2.
Antimalarials (Antimalarial Agents)
3.
Mefloquine (Lariam)
4.
Cytokines
5.
Interleukin-6 (Interleukin 6)
6.
Lipopolysaccharides
7.
Antigens
8.
yingzhaosu A