complanatuside

isolated from seeds of Astragalus complanatus R. Brown; structure given in first source

Also Known As:

rhamnocitrin-3,4'-O-diglucoside; 4H-1-Benzopyran-4-one, 3-(beta-D-glucopyranosyloxy)-2-(4-(beta-D-glucopyranosyloxy)phenyl)-5-hydroxy-7-methoxy-

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

1.	Inflammation (Inflammations) 01/01/2022 - "Results of the present study indicate that complanatuside inhibited inflammation and protected the cells from inflammatory cell damage in HaCaT cells treated with the combination of IFN-γ, TNF-α, and IL-6. " 01/01/2022 - "The aim of this study is to explore the inhibitory effect of complanatuside on inflammation and its underlying mechanisms in skin epithelial HaCaT cells treated with inflammatory cytokines. "
2.	Erectile Dysfunction 06/01/2022 - "As a result, complanatuside, astragalin, complanatoside B, and kaempferol were found to be responsible for anti-erectile dysfunction effect of Astragali Complanati."
3.	Dehydration (Water Stress) 12/25/2018 - "The UHPLC-Q-TOF/MS (ultra-high performance liquid chromatography coupled with electrospray ionization tandem quadrupole-time-of-flight mass spectrometry) method was applied to identify the metabolites of complanatuside in rat plasma, bile, stool, and urine after oral administration at the dosage of 72 mg/kg. Up to 34 metabolites (parent, 2 metabolites of the parent drug, and 31 metabolites of the degradation products) were observed, including processes of demethylation, hydroxylation, glucuronidation, sulfonation, and dehydration. "
4.	COVID-19 01/01/2022 - "Complanatuside may be a promising candidate for inhibiting COVID-19 related skin inflammatory damage."

1.	Oral Administration