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1-ethynylpyrene
RN & structure given in first source; RN not in Chemline 12/84
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Pyrenes: 10
1-ethynylpyrene: 2
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Pyrenes: 10
1-ethynylpyrene: 2
Related Diseases
1.
Neoplasms (Cancer)
07/01/1991 - "
A single dose of 1-ethynylpyrene (EP), 1-vinylpyrene (VP) or 2-ethynylnaphthalene (EN) was applied to the skin of SENCAR mice 5 min before an initiating dose of 7,12-dimethylbenz[a]anthracene (DMBA) or benzo[a]pyrene (B[a]P) and the development of skin tumors then promoted with biweekly topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA).
"
2.
Hepatocellular Carcinoma (Hepatoma)
12/01/1999 - "
1-ethynylpyrene (1EP) selectively inactivated CYP1B1 dimethylbenzanthracene (DMBA) metabolism in C3H10T1/2 MEFs; whereas 1-(1-propynyl)pyrene (1PP) preferentially inhibited CYP1A1 activity in Hepa-1c1c7 mouse hepatoma cells (Hepa).
"
Related Drugs and Biologics
1.
Cytochrome P-450 CYP1A1 (CYP1A1)
2.
Benzo(a)pyrene
3.
1-(1-propynyl)pyrene
4.
2-ethynylnaphthalene
5.
1-vinylpyrene
6.
anthracene