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FPL 57231
LTD4 receptor antagonist; structure given in first source
Also Known As:
FPL-57231; 4H-1-Benzopyran-2-propanoic acid, 7-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy)-4-oxo-8-propyl-
Networked:
9
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Chromones: 159
FPL 57231: 9
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Chromones: 159
FPL 57231: 9
Related Diseases
1.
Pulmonary Hypertension
05/01/1985 - "
Leukotriene inhibition with FPL 57231 may be useful in the management of infants with persistent pulmonary hypertension syndrome.
"
11/01/1985 - "
In order to elucidate the role of leukotrienes in hypoxic pulmonary hypertension in a young animal model, the effects of a leukotriene antagonist, FPL 57231, were evaluated in anesthetized piglets.
"
2.
Hypoxia (Hypoxemia)
11/01/1985 - "
In addition, pretreatment with FPL 57231 attenuated the hemodynamic response to hypoxia.
"
11/01/1985 - "
These measurements were compared during continued hypoxia between a control and treatment group which received FPL 57231.
"
05/01/1985 - "
The hypoxia-induced increase in cardiac output was maintained during the infusion of FPL 57231.
"
05/01/1985 - "
The infusion of FPL 57231 during hypoxia-induced pulmonary vasoconstriction reversed the increase in pulmonary arterial pressure (p less than 0.05) and pulmonary vascular resistance (p less than 0.05).
"
09/01/1989 - "
Similarly, the LT receptor antagonists FPL 57231 (3 microM) or LY 163443 (1 microM), at concentrations that inhibited LT-induced venular contractions, did not significantly affect the responses to hypoxia or anoxia.
"
3.
Sepsis (Septicemia)
09/01/1988 - "
In order to evaluate the role of leukotrienes in group B streptococcal (GBS) sepsis we studied the effect of a leukotriene receptor antagonist, FPL 57231, on the late hemodynamic changes occurring secondary to an infusion of live GBS.
"
10/01/1986 - "
In order to evaluate the influence of leukotrienes on group B streptococcal (GBS) sepsis we studied the effect of a leukotriene antagonist, FPL 57231, on the early hemodynamic changes occurring secondary to an infusion of live GBS.
"
4.
Septic Shock (Toxic Shock Syndrome)
01/01/1987 - "
We studied the effects of a selective leukotriene (LT) antagonist (FPL 57231, 2 mg kg-1 min-1) on the acute cardiopulmonary changes observed in feline endotoxin shock.
"
5.
Respiratory Hypersensitivity
09/01/1986 - "
Indomethacin and FPL-57231 inhibit antigen-induced airway hyperresponsiveness in sheep.
"
Related Drugs and Biologics
1.
Leukotrienes
2.
Leukotriene Antagonists (Leukotriene Receptor Antagonists)
3.
Leukotriene Receptors (Leukotriene Receptor)
4.
Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
5.
Indomethacin (Indometacin)
6.
Histamine (Histamine Dihydrochloride)
7.
Carbachol (Carbastat)
8.
Aspirin (Acetylsalicylic Acid)
9.
Antigens
10.
LY 163443