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amafolone
RN given refers to parent cpd; NM refers to HCl
Also Known As:
3 alpha-amino-5 alpha-androstan-2 beta-ol-17-one.HCl; Org 6001; Org-6001; amafalone; amafolone hydrochloride; (2 beta,3 alpha,5 alpha)-3-amino-2-hydroxyandrostan-17-one, hydrochloride
Networked:
9
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Androstanes: 11
Androstanols
amafolone: 9
Related Diseases
1.
Ventricular Fibrillation
02/01/1982 - "
The antiarrythmic effect of Org 6001, as measured by changes in the incidence of ventricular fibrillation, correlated with myocardial concentrations of the drug.
"
02/01/1982 - "
Org 6001 (10, 20, 50 and 100 mg/kg given 1 h before ligation) significantly reduced mortality and the incidence of ventricular fibrillation in the 0-30 min post ligation period.
"
08/01/1979 - "
The effect of aminosteroid, ORG 6001, on hypothermia induced ventricular fibrillation in the cat.
"
10/01/1981 - "
6 Org 6001 and mexiletine differed in their actions on ventricular fibrillation threshold (VFT).
"
07/01/1980 - "
Prolonged oral administration of Org 6001, 10 mg/kg twice daily for 10 days, the last dose given 1 hr before ligation, reduced the incidence of ventricular fibrillation and increased survival in both conscious and anesthetized animals.
"
2.
Coronary Occlusion
10/01/1977 - "
The antidysrhythmic aminosteroid, ORG 6001, reduces the ST-segment elevation produced by coronary occlusion in the dog.
"
3.
Infarction (Infarctions)
06/01/1980 - "
In this model, lignocaine (10 mg/kg plus an infusion of 5 mg/kg/hr) and ORG 6001 (10 mg/kg plus an infusion of 2.5 mg/kg/hr) had marked antidysrhythmic activity but neither drug influenced infarct size.
"
4.
Hypotension (Low Blood Pressure)
10/01/1981 - "
3 In antidysrhythmic doses, Org 6001 and mexiletine exerted only moderate and transient hypotension and depression of cardiac contractility (assessed from LV dP/dtmax).
"
5.
Bradycardia
10/01/1981 - "
Org 6001 did, however, induce a more sustained bradycardia.
"
Related Drugs and Biologics
1.
Lidocaine (Xylocaine)
2.
Encainide
3.
Ouabain (G Strophanthin)
4.
lorcainide
5.
Sodium
6.
Bepridil (Vascor)
7.
Potassium
8.
Pentobarbital (Nembutal)
9.
Mexiletine (Mexitil)
10.
metylperon (melperone)
Related Therapies and Procedures
1.
Ligation
2.
Induced Hypothermia
3.
Oral Administration