cholesteryl sulfate

component of human seminal plasma & spermatozoa; RN given refers to (3beta)-isomer

Also Known As:

cholesterol sulfate; cholesteryl sulfate, 3H-labeled, (3beta)-isomer; cholesteryl sulfate, ammonium salt, (3beta)-isomer; cholesteryl sulfate, potassium salt, (3beta)-isomer; cholesteryl sulfate, sodium salt, (3beta)-isomer; cholesteryl sulfate, sodium salt, 26-(14)C-labeled

Networked: 87 relevant articles (3 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mi-Ichi, Fumika: 3 articles (01/2022 - 11/2017)
2.	Yoshida, Hiroki: 3 articles (01/2022 - 11/2017)
3.	Cooks, R Graham: 3 articles (01/2016 - 05/2010)
4.	Bamba, Takeshi: 2 articles (01/2023 - 01/2022)
5.	Fukui, Yoshinori: 2 articles (01/2023 - 01/2022)
6.	Izumi, Yoshihiro: 2 articles (01/2023 - 01/2022)
7.	Kunimura, Kazufumi: 2 articles (01/2023 - 01/2022)
8.	Sakata, Daiji: 2 articles (01/2023 - 01/2022)
9.	Sugiura, Yuki: 2 articles (01/2023 - 01/2022)
10.	Uruno, Takehito: 2 articles (01/2023 - 01/2022)

Related Diseases

1.	X-Linked Ichthyosis (Ichthyosis, X Linked) 10/21/2021 - "In particular, accumulation of intracellular cholesterol sulfate by STS deficiency leads to a skin disorder with abnormal keratinization called X-linked ichthyosis (XLI). " 03/01/2014 - "Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis." 04/01/2008 - "For example, in recessive X-linked ichthyosis (RXLI), cholesterol sulfate (CSO(4)) accumulation also produces a permeability barrier defect through lamellar/nonlamellar phase separation. " 04/01/2007 - "STS deficiency in X-linked ichthyosis leads to cholesterol sulfate accumulation, which induces transglutaminase-1 dysfunction. " 11/01/1998 - "[X-linked ichthyosis: development of a new cellular and metabolic model of cholesterol sulfate]."
2.	Hypercholesterolemia 09/01/1993 - "Higher levels of plasma cholesterol sulfate in patients with liver cirrhosis and hypercholesterolemia." 05/15/2024 - "This pseudo-targeted lipidomics study demonstrated that multiple sphingomyelins and cholesterol sulfate were differentially expressed in the plasma of patients with hypercholesterolemia. " 07/01/1981 - "Eight subjects (age 3 months-74 years) with steroid sulfatase deficiency had strikingly elevated cholesterol sulfate levels with means and ranges as follows: plasma - 3,300 micrograms/100 ml (2,700-4,000), red cell membranes- 7,500 (5,200-9,800) Cholesterol sulfate is known to effect membrane stability and the present observations may help to explain the pathogenesis of STS deficiency and x-linked ichthyosis." 05/15/2024 - "The levels of eight sphingomyelins and cholesterol sulfate were higher and those of three triacylglycerols and lysophosphatidylcholine were reduced in hypercholesterolemia. "
3.	Ulcerative Colitis 01/01/2022 - "In conclusion, cholesterol sulfate contributes to the healing of the mucosal barrier and exhibits therapeutic efficacy against ulcerative colitis in mice." 01/01/2022 - "Herein, we study the functional role and underlying intestinal epithelial repair mechanisms of cholesterol sulfate in ulcerative colitis. " 01/01/2022 - "The levels of cholesterol and cholesterol sulfate, as well as the expression of Sult2b1 and genes involved in cholesterol biosynthesis, are significantly higher in inflamed tissues from patients with ulcerative colitis than in intestinal mucosa from healthy controls. " 01/01/2022 - "Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells." 01/01/2022 - "Specific deletion of the Sult2b1 gene in the intestinal epithelial cells aggravates dextran sulfate sodium-induced colitis; however, dietary supplementation with cholesterol sulfate ameliorates this effect in acute and chronic ulcerative colitis in mice. "
4.	Infections 07/01/2014 - "infection leads to increased presence of cholesteryl sulfate in this tissue. " 04/01/1989 - "Amphotericin B-deoxycholate given iv at a dose of 1.5 mg/kg was more effective in sterilizing liver and kidney than the amphotericin/cholesterol-sulfate complexes given iv at 1.5-4.5 mg/kg, but infection persisted in the lungs of all rabbits treated with those doses. " 01/01/2023 - "marneffei infection after renal transplantation is very high, timely and effective antifungal therapy with amphotericin B cholesteryl sulfate complex is still expected to improve its prognosis." 06/01/2022 - "The infection was treated with amphotericin B cholesteryl sulfate complex, posaconazole, and interventional surgery, and the treatment was successful. " 04/01/1989 - "Infection persisted even when the rabbits were given a lethal dose of amphotericin B-deoxycholate (4.5 mg/kg), but a dose of 15 mg/kg of the amphotericin/cholesterol-sulfate complexes sterilized tissues and was associated with no acute lethality. "
5.	Aspergillosis 04/01/1989 - "An immunosuppressed rabbit model of invasive aspergillosis was used to evaluate a novel micellar preparation of cholesterol sulfate complexed to amphotericin B. " 04/01/1989 - "Treatment of experimental invasive aspergillosis with novel amphotericin B/cholesterol-sulfate complexes." 04/01/1989 - "The amphotericin/cholesterol-sulfate complexes appear to be an improved means of amphotericin B delivery and may improve therapy for invasive aspergillosis." 01/01/1998 - "In November 1996, amphotericin B cholesteryl sulfate complex for injection (Amphotec, Sequus Pharmaceuticals, Menlo Park, CA), a second preparation composed of a disc-like structure, received FDA approval for the treatment of invasive aspergillosis in patients in whom renal impairment or unacceptable toxicity precludes the use of conventional AmB therapy and in patients in whom prior AmB therapy has failed. "

Related Drugs and Biologics

1.	Amphotericin B (Amphotericin)
2.	Sulfates (Sulfates, Inorganic)
3.	Dextran Sulfate
4.	deoxycholate drug combination amphotericin B
5.	Steryl-Sulfatase (Steroid Sulfatase)
6.	Cholesterol
7.	Lipids
8.	Enzymes
9.	Sulfotransferases
10.	Phospholipids (Phosphatides)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Kidney Transplantation
4.	Drug Therapy (Chemotherapy)