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ML-162

Also Known As:

2-(3-chloro-N-(2-chloroacetyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide; ML162

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - ML-162: 2
- Sulfur Compounds: 278
  - Thiophenes: 257
    - ML-162: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - ML-162: 2

Experts

1.	Bittker, Joshua A: 1 article (02/2012)
2.	Dandapani, Sivaraman: 1 article (02/2012)
3.	Lewis, Timothy A: 1 article (02/2012)
4.	MacPherson, Lawrence: 1 article (02/2012)
5.	Munoz, Benito: 1 article (02/2012)
6.	Palmer, Michelle: 1 article (02/2012)
7.	Schreiber, Stuart L: 1 article (02/2012)
8.	Shimada, Kenichi: 1 article (02/2012)
9.	Stockwell, Brent R: 1 article (02/2012)
10.	Weïwer, Michel: 1 article (02/2012)

Related Diseases

1.

Neoplasms (Cancer)

01/01/2022 - "We demonstrate that a rationally designed GPX4 degrader, dGPX4, can deplete tumor cell GPX4 via proteasomal protein degradation, showing a five-fold enhancement of ferroptosis induction efficiency compared to that of GPX4 inhibition using ML162. "
02/15/2012 - "This effort led to the identification of two novel molecular probes (PubChem CID 3689413, ML162 and CID 49766530, ML210) with nanomolar potencies and 4-23-fold selectivities, which can potentially be used for identifying oncogene-specific pathways and targets in cancer cells."

Related Drugs and Biologics

1.	Molecular Probes (Molecular Probe)
2.	(4- (bis(4- chlorophenyl)methyl)- 1- piperazinyl)(5- methyl- 4- nitro- 1,2- oxazol- 3- yl)methanone