shikimate

Also Known As:

(3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate; (3R,4S,5R)-3,4,5-trihydroxy-1-cyclohexene-1-carboxylate; 1-cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-, ion(1-), (3R,4S,5R)-

Networked: 59 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexenes: 4
        Shikimic Acid: 52
        shikimate: 59
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Shikimic Acid: 52
      - shikimate: 59
  - Carbocyclic Acids
    - Cyclohexanecarboxylic Acids
      - Shikimic Acid: 52
        shikimate: 59

Experts

1.	Basso, Luiz Augusto: 3 articles (01/2013 - 12/2004)
2.	Palma, Mário Sérgio: 3 articles (01/2013 - 12/2004)
3.	Santos, Diógenes Santiago: 3 articles (01/2013 - 12/2004)
4.	Christendat, Dinesh: 2 articles (01/2022 - 06/2006)
5.	Choi, Si-Sun: 2 articles (12/2021 - 09/2021)
6.	Kim, Eung-Soo: 2 articles (12/2021 - 09/2021)
7.	Lee, Han-Na: 2 articles (12/2021 - 09/2021)
8.	Lee, Sang Joung: 2 articles (12/2021 - 09/2021)
9.	Park, Eunhwi: 2 articles (12/2021 - 09/2021)
10.	Seo, Seung-Yeul: 2 articles (12/2021 - 09/2021)

Related Diseases

1.	Malaria 01/01/2021 - "We propose shikimate 3-phosphate for targeting liver-stage malaria with minimal impact on the human host cell. " 01/01/1999 - "Targeting the shikimate pathway in the malaria parasite Plasmodium falciparum." 01/01/2018 - "In Plasmodium, the shikimate pathway is a potential target for malaria chemotherapy owing to its absence in the mammalian host. " 01/01/1999 - "The shikimate pathway presents an attractive target for malaria chemotherapy. " 12/01/2003 - "Our studies suggest that the PABA content in the diet will affect the host clearance of malaria parasites and may affect the efficacy of treatments that target the shikimate pathway."
2.	Bacterial Infections (Bacterial Infection) 12/03/2003 - "Vaccination with bacterial auxotrophs, particularly those with an interruption in the common pathway of aromatic amino-acid biosynthesis, known as the shikimate pathway, has been shown to be effective in the prevention of a variety of bacterial diseases. "
3.	Tuberculosis (Tuberculoses) 08/01/2008 - "tuberculosis (MtSDH), which catalyses the fourth step of the shikimate pathway. " 05/01/2008 - "New tuberculosis drug development: targeting the shikimate pathway." 10/08/2020 - "In this study, we have investigated the enzyme shikimate 5-dehydrogenase from the causative agent of tuberculosis, Mycobacterium tuberculosis. " 04/25/2023 - "The shikimate pathway, which produces aromatic amino acids and key intermediates, is critical to the viability of the tuberculosis-causing pathogen Mycobacterium tuberculosis. " 01/01/2015 - "3-Dehydroquinase, the third enzyme in the shikimate pathway, is a potential target for drugs against tuberculosis. "
4.	Wounds and Injuries (Trauma) 06/01/2020 - "The study was conducted to get novel information about the B-deficient-induced cellular injuries and target secondary metabolites in the shikimate pathway. " 01/14/2016 - "These pathways were associated with secondary metabolite production, primary carbohydrate metabolic pathways, shikimate derivative dependent pathways, ribosomal subunit composition, hormone signaling, wound response, cell wall formation, and anti-oxidant defense. " 01/01/2014 - "Deficiencies in serotonin, due to disruption of the shikimate pathway, may lead to impaired melatonin supply, which reduces the resiliency of the brain through reduced antioxidant capacity and alterations in the cerebrospinal fluid, reducing critical protective buffering mechanisms in impact trauma. "
5.	Infections 05/08/2023 - "The shikimate pathway may act as a hub between glucose metabolism and phenylpropanoid metabolism during Agrobacterium infection. " 11/01/2021 - "cinerea infection, including genes encoding proteins with known functions in angiosperm immunity and involved in pathogen perception, signaling, transcription, hormonal signaling, metabolic pathways such as shikimate and phenylpropanoid, and proteins with diverse role in defense against biotic stress. " 01/01/2018 - "Genes that were highly regulated in response to infection in both shoot and root primarily were involved in the metabolism of cell wall compounds, lipids, and shikimate pathway metabolites. " 12/01/2023 - "Caffeoyl shikimate esterase (CSE), a key enzyme in the lignin biosynthetic pathway, has recently been characterized to play a key role in defense against pathogenic infection in plants. " 01/01/2013 - "We show that genes encoding enzymes of the purine, pyrimidine, and shikimate biosynthesis pathways are critical for virulence in multiple host models of infection."

Related Drugs and Biologics

1.	4-Aminobenzoic Acid (4 Aminobenzoic Acid)
2.	Aromatic Amino Acids (Aromatic Amino Acid)
3.	Enzymes
4.	Lignin
5.	Coenzyme A (CoA)
6.	Oseltamivir (Tamiflu)
7.	Transcription Factors (Transcription Factor)
8.	Phenylalanine (L-Phenylalanine)
9.	Ligases (Synthetase)
10.	Adenosine Diphosphate (ADP)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)