Targeting the shikimate pathway in the malaria parasite Plasmodium falciparum.

Abstract

The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 x 10(-5) and 2.7 x 10(-4) M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the inhibition, demonstrating that the shikimate pathway was specifically targeted.

• Authors: G A McConkey
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 43 Issue 1 Pg. 175-7 (Jan 1999) ISSN: 0066-4804 [Print] United States
• PMID: 9869588 (Publication Type: Journal Article)

Chemical References

• 2-fluoroshikimic acid
• 6-fluoroshikimic acid
• Antimalarials
• Shikimic Acid
• 4-Aminobenzoic Acid

Topics

• 4-Aminobenzoic Acid (pharmacology)
• Animals
• Antimalarials (pharmacology)
• Plasmodium falciparum (drug effects, growth & development, metabolism)
• Shikimic Acid (analogs & derivatives, metabolism, pharmacology)
• Stereoisomerism