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N- ((1R)- 2- (tertbutylamino)- 2- oxo- 1- (3- pyridyl)ethyl)- N- (4- tertbutylphenyl)furan- 2- carboxamide

Also Known As:

ML-188; ML188

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - N-((1R)-2-(tertbutylamino)-2-oxo-1-(3-pyridyl)ethyl)-N-(4-tertbutylphenyl)furan-2-carboxamide: 2
Organic Chemicals: 133
- Amides: 2428
  - Acetamides: 21
    - Benzeneacetamides
      - N-((1R)-2-(tertbutylamino)-2-oxo-1-(3-pyridyl)ethyl)-N-(4-tertbutylphenyl)furan-2-carboxamide: 2
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzeneacetamides
        N-((1R)-2-(tertbutylamino)-2-oxo-1-(3-pyridyl)ethyl)-N-(4-tertbutylphenyl)furan-2-carboxamide: 2

Experts

1.	Aghaee, Elham: 1 article (01/2021)
2.	Ghasemi, Jahan B: 1 article (01/2021)
3.	Ghodrati, Marzieh: 1 article (01/2021)
4.	Baez-Santos, Yahira M: 1 article (01/2013)
5.	Baker, Susan C: 1 article (01/2013)
6.	Chase, Peter: 1 article (01/2013)
7.	Dawson, Eric S: 1 article (01/2013)
8.	Eggler, Aimee: 1 article (01/2013)
9.	Grum-Tokars, Valerie: 1 article (01/2013)
10.	Hodder, Peter: 1 article (01/2013)

Related Diseases

1.	COVID-19 01/01/2021 - "This study indicates that the interaction energy of the top ten retrieved compounds with COVID-19 main protease is much higher than the interaction energy of some currently in use protease drugs such as ML188, nelfinavir, lopinavir, ritonavir, and α-ketoamide. "
2.	Severe Acute Respiratory Syndrome 01/24/2013 - "A high-throughput screen of the NIH molecular libraries sample collection and subsequent optimization of a lead dipeptide-like series of severe acute respiratory syndrome (SARS) main protease (3CLpro) inhibitors led to the identification of probe compound ML188 (16-(R), (R)-N-(4-(tert-butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide, Pubchem CID: 46897844). "

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	Lopinavir
3.	Nelfinavir (Viracept)
4.	Ritonavir (Norvir)
5.	Dipeptides
6.	furan