spaceflight-induced visual impairment

Visual impairments and intracranial pressure changes developed during prolonged exposure to MICROGRAVITY in SPACE FLIGHT.

Also Known As:

SANS spaceflight-associated neuro-ocular syndrome; VIIP spaceflight-associated; space flight-associated VIIP; space flight-associated neuro-ocular syndrome; space flight-induced visual impairment; spaceflight-associated VIIP; spaceflight-associated neuro-ocular syndrome; spaceflight-associated visual impairment and intracranial pressure syndrome

Networked: 13 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease)

Experts

1.	Lee, Andrew G: 4 articles (07/2024 - 01/2021)
2.	Ong, Joshua: 3 articles (07/2024 - 01/2021)
3.	Waisberg, Ethan: 2 articles (07/2024 - 05/2024)
4.	Bloomberg, Jacob J: 2 articles (03/2024 - 01/2021)
5.	Lee, Jessica K: 2 articles (03/2024 - 01/2021)
6.	Mulder, Edwin: 2 articles (03/2024 - 01/2021)
7.	Seidler, Rachael D: 2 articles (03/2024 - 01/2021)
8.	Levine, Benjamin D: 2 articles (01/2022 - 01/2019)
9.	Petersen, Johan C G: 2 articles (01/2022 - 01/2019)
10.	Petersen, Lonnie G: 2 articles (01/2022 - 01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to spaceflight-induced visual impairment:

1.	Fluorescein (Funduscein)FDA LinkGeneric 07/01/2024 - "To provide an automated system for synthesizing fluorescein angiography (FA) images from color fundus photographs for averting risks associated with fluorescein dye and extend its future application to spaceflight associated neuro-ocular syndrome (SANS) detection in spaceflight where resources are limited. "
2.	ElementsIBA 01/01/2023 - "We propose a new theory for the driving force leading to the development of Spaceflight-Associated Neuro-ocular Syndrome which is described via a finite element model of the eye and orbit. "
3.	Coloring Agents (Dyes)IBA 07/01/2024 - "To provide an automated system for synthesizing fluorescein angiography (FA) images from color fundus photographs for averting risks associated with fluorescein dye and extend its future application to spaceflight associated neuro-ocular syndrome (SANS) detection in spaceflight where resources are limited. "
4.	4-(2-oxapentadeca-4-yne)phenylpropanoic acidIBA 01/01/2022 - "Changes in OPP as a function of changes in gravitational stress and/or weightlessness may play a role in the pathogenesis of spaceflight-associated neuro-ocular syndrome.NEW & NOTEWORTHY Maintaining appropriate ocular perfusion pressure (OPP) is critical for ocular health. " 01/01/2022 - "We demonstrate that OPP is more gravitationally dependent than previously recognized and may be a factor in the overall patho-etiology behind the weightlessness-induced spaceflight-associated neuro-ocular syndrome."
5.	A-factor (Streptomyces)IBA 01/01/2022 - "We demonstrate that OPP is more gravitationally dependent than previously recognized and may be a factor in the overall patho-etiology behind the weightlessness-induced spaceflight-associated neuro-ocular syndrome."
6.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/01/2019 - "An LBNP of 20 mmHg may be the optimal level to lower ICP without impairing CPP to counteract spaceflight-associated neuro-ocular syndrome in astronauts. "

Therapies and Procedures

1.	Bed Rest (Bedrest) 01/01/2021 - "Head-Down Tilt Bed Rest Studies as a Terrestrial Analog for Spaceflight Associated Neuro-Ocular Syndrome." 03/01/2024 - "Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest." 12/01/2022 - "These results indicate that strict 6° HDT bed rest produced displacement of the posterior globe with a trend of increasing displacement with longer duration that was not prevented by daily 30 min exposure to AG.NEW & NOTEWORTHY Head-down tilt (HDT) bed rest is commonly used as a spaceflight analog for investigating spaceflight associated neuro-ocular syndrome (SANS). " 10/01/2021 - "As part of our investigations of intraocular pressure (IOP) as a potential contributing factor to the spaceflight-associated neuro-ocular syndrome using the 6° head-down tilt (6°HDT) bed rest experimental model, we compared the effect of rest and isometric exercise in prone and supine 6°HDT positions on IOP with that observed in the seated position. " 01/01/2021 - "These findings have important implications for missions and mission training, which require individuals to adapt to altered sensory inputs over long periods in space.NEW & NOTEWORTHY This is the first bed rest campaign examining sensorimotor adaptation and savings in response to the combined effect of HDBR + CO2 and to observe signs of spaceflight-associated neuro-ocular syndrome (SANS) in HDBR participants. "
2.	Lower Body Negative Pressure 01/01/2022 - "Effect of Nightly Lower Body Negative Pressure on Choroid Engorgement in a Model of Spaceflight-Associated Neuro-ocular Syndrome: A Randomized Crossover Trial." 01/01/2022 - "Lower Body Negative Pressure as a Potential Countermeasure for Spaceflight-Associated Neuro-Ocular Syndrome." 01/01/2019 - "An LBNP of 20 mmHg may be the optimal level to lower ICP without impairing CPP to counteract spaceflight-associated neuro-ocular syndrome in astronauts. "
3.	Therapeutics 05/03/2024 - "Near infrared/ red light therapy a potential countermeasure for mitochondrial dysfunction in spaceflight associated neuro-ocular syndrome (SANS)."
4.	Eye Protective Devices (Goggles) 01/01/2019 - "Association of Exercise and Swimming Goggles With Modulation of Cerebro-ocular Hemodynamics and Pressures in a Model of Spaceflight-Associated Neuro-ocular Syndrome."