anti-dsDNA autoantibody

autoantibodies found in LUPUS ERYTHEMATOSUS, SYSTEMIC

Also Known As:

Anti-double stranded DNA autoantibodies; Anti-double stranded DNA autoantibody; Anti-double-stranded DNA antibody; Anti-dsDNA antibodies; Anti-dsDNA antibody; Anti-dsDNA autoantibodies

Networked: 809 relevant articles (41 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rekvig, Ole Petter: 13 articles (01/2020 - 01/2005)
2.	Chan, Tak Mao: 12 articles (06/2021 - 09/2008)
3.	Yung, Susan: 11 articles (06/2021 - 09/2008)
4.	Putterman, Chaim: 7 articles (12/2012 - 02/2005)
5.	Xiong, Sidong: 6 articles (05/2015 - 07/2005)
6.	Mohan, Chandra: 5 articles (01/2022 - 02/2005)
7.	Sun, Lingyun: 5 articles (01/2021 - 12/2009)
8.	Sun, Kuang-Hui: 5 articles (01/2020 - 08/2010)
9.	Bengtsson, Anders A: 5 articles (11/2019 - 01/2014)
10.	Jönsen, Andreas: 5 articles (11/2019 - 01/2014)

Related Diseases

1.	Proteinuria 01/01/2015 - "In comparison with untreated MRL/lpr mice, mice treated with 1.2 and 0.6 mg/10 g of T-96 showed a significant improvement in 24 h proteinuria and the levels of anti-dsDNA antibody in serum. " 01/01/2007 - "Results in the SR-treated group showed a significant reduction in proteinuria and anti-dsDNA antibodies either in serum or in glomerular capillaries, along with significant recovery from renal glomerular damage. " 01/01/2019 - "The results confirmed that pMSC treatment reduced the severity of 24-h proteinuria, decreased the production of anti-dsDNA antibodies, and ameliorated renal pathological changes in MRL/lpr mice. " 11/01/2016 - "Infusion of MDSCs resulted in a reduction of serum anti-double-stranded DNA antibody levels and degree of proteinuria and an improvement in renal pathology in the roquinsan/san mice. " 06/01/2011 - "In addition, the anti-CD20 reduced serum anti-dsDNA antibody levels, impeded the development of proteinuria and improved the survival of BWF1 mice. "
2.	Lupus Nephritis 01/01/2021 - "Administration of EZH2 inhibitor prolonged the survival, reduced the levels of anti-dsDNA autoantibodies, and improved lupus nephritis of the mice. " 01/01/2020 - "In sum, this study is an attempt to bring to the forum critical comments on the contemporary definition and classification of SLE, lupus nephritis and anti-dsDNA antibodies. " 01/01/2020 - "This study is an attempt to prioritize critical comments on the contemporary definition and classification of SLE and of anti-dsDNA antibodies in context of lupus nephritis. " 06/01/2023 - "High expression of miR-199a-3p was correlated with several clinical characteristics including low C3 level, positive anti-dsDNA antibody, high ESR level, active lupus nephritis, and active disease activity. " 01/01/2022 - "Anti-dsDNA antibodies, serum, or plasma from individuals with lupus nephritis, or specific pathologic factors activated multiple signaling pathways. "
3.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 07/01/2023 - "This study aimed to compare the YHLO chemiluminescence immunoassay (CLIA) with the Crithidia luciliae immunofluorescence test (CLIFT) to detect anti-dsDNA antibodies and its correlation with disease activity in systemic lupus erythematosus (SLE). " 01/01/2018 - "Cigarette smoking and the risk of systemic lupus erythematosus, overall and by anti-double stranded DNA antibody subtype, in the Nurses' Health Study cohorts." 12/01/2010 - "The objective of this study is to evaluate the specificity and sensitivity of antinucleosome, anti-C1q, and anti-dsDNA antibodies for detecting concurrent disease activity in systemic lupus erythematosus (SLE). " 01/01/1997 - "These results represent a conceptual advance in understanding a potential molecular basis for initiation of autoimmunity in systemic lupus erythematosus and establish a precedent for further studies on polyomavirus expression as one biological origin for anti-dsDNA antibodies in human lupus." 12/01/2023 - "Anti-dsDNA autoantibodies are listed as one of the classification criteria for systemic lupus erythematosus (SLE) and are relatively effective indicators for monitoring disease activity and treatment response. "
4.	Nephritis 04/01/2007 - "In this study, we analyzed renal tissue from anti-dsDNA antibody-positive lupus patients with nephritis by morphological and immunological assays, including immune electron microscopy (IEM) and colocalization IEM, an EM-based confocal microscopy assay. " 01/01/2004 - "A pivotal study demonstrated the ability of CTLA4Ig to suppress the production of anti-dsDNA antibodies and decrease nephritis in lupus prone mice. " 10/01/1996 - "We have used the GBA to study sera from four groups of SLE patients: (A) + anti-dsDNA antibodies, active nephritis; (B) - anti-dsDNA antibodies, active nephritis; (C) + anti-dsDNA antibodies, no nephritis; and (D) - anti-dsDNA antibodies, no nephritis. " 01/01/2023 - "No association was observed between age, sex, anti-double-stranded-DNA antibody, anti-Smith antibody, eGFR, and proliferative nephritis. " 01/01/2023 - "In this retrospective, observational study, multivariate logistic regression and receiver operating characteristic (ROC) analyses studied age, sex, race, serum complements, anti-double-stranded-DNA antibody, anti-Smith antibody, eGFR, and proliferative nephritis. "
5.	Glomerulonephritis 09/27/2019 - "Moreover, aged PKN1[T778A] mice showed no obvious GC formation nor autoimmune-like phenotypes, such as glomerulonephritis or increased anti-dsDNA antibody titer, in peripheral blood. " 01/01/2019 - "Anti-Ku patients with elevated CK had a 22-fold higher risk of ILD while anti-Ku patients with anti-dsDNA antibodies had a 13-fold higher risk of glomerulonephritis CONCLUSION: "Anti-Ku with elevated CK" syndrome and "anti-Ku with anti-dsDNA" syndrome represent two distinct entities that are important to recognise in order to best tailor patient care." 02/01/2017 - "Elevated levels of S100A8/A9 were particularly seen in patients with anti-dsDNA antibodies ( p = 0.01) and glomerulonephritis before treatment ( p = 0.02). " 08/01/2013 - "In addition, anti-dsDNA antibodies deposit in kidneys to initiate glomerulonephritis. " 03/01/2013 - "Anti-dsDNA antibodies are present before the onset of clinical disease and are associated with severe manifestations of lupus such as glomerulonephritis. "

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	DNA (Deoxyribonucleic Acid)
3.	Proteins (Proteins, Gene)
4.	Creatinine
5.	Antigen-Antibody Complex (Immune Complex)
6.	Cytokines
7.	anti-dsDNA autoantibody
8.	Sirolimus (Rapamycin)
9.	Antibodies
10.	Prednisone (Sone)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Therapeutics
3.	Transplantation
4.	Blood Component Removal (Apheresis)
5.	Oral Administration