celastrol methyl ester

isolated from Tripterygium wilfordii; potent inhibitory activity on both Kir2.1 and ERG1 potassium channels, leading to LONG QT SYNDROME

Also Known As:

(9 beta,13 alpha,14 beta, 20 alpha)-3-hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid; 3-hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid methyl ester; pristimerin

Networked: 91 relevant articles (7 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Pentacyclic Triterpenes: 108
        celastrol methyl ester: 91

Experts

1.	Deeb, Dorrah: 7 articles (07/2016 - 11/2013)
2.	Gao, Xiaohua: 7 articles (07/2016 - 11/2013)
3.	Gautam, Subhash C: 7 articles (07/2016 - 11/2013)
4.	Bi, Yun: 5 articles (11/2021 - 01/2019)
5.	Zhao, Qun: 5 articles (11/2021 - 01/2019)
6.	Jiang, Zhen-Zhou: 5 articles (02/2018 - 01/2012)
7.	Zhang, Lu-Yong: 5 articles (02/2018 - 01/2012)
8.	Pan, Jingxuan: 4 articles (12/2021 - 05/2010)
9.	Yu, Xianjun: 4 articles (11/2021 - 01/2019)
10.	Huang, Shuai: 4 articles (06/2021 - 01/2015)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2018 - "Here, we found that pristimerin inhibited ESCC cell proliferation, migration, invasion, induced cell apoptosis, and eliminated cancer stem-like cells (CSCs). " 10/01/2022 - "This study presented the anti-tumor mechanism of pristimerin by literature review, which might serve as a reference for further research and clinical practice." 12/01/2021 - "In vivo studies using xenograft mouse model demonstrated that pristimerin inhibited tumor growth. " 01/01/2021 - "Recent studies have identified alterations in cellular events and molecular signaling targets of cancer cells under pristimerin treatment. " 04/01/2016 - "In the present study, we further evaluated pristimerin anti-tumor and anti-metastatic properties. "
2.	Breast Neoplasms (Breast Cancer) 11/01/2018 - "The present study investigated the autophagy‑induced anticancer efficacy of pristimerin on MDA‑MB‑231 human breast cancer cells. " 01/01/2020 - "We observed that pristimerin inhibited breast cancer cell viability, migration, and cell cycle, meanwhile induced cell apoptosis. " 01/01/2020 - "Bioinformatic analysis was used to find the underlying molecular and gene connected with pristimerin and breast cancer survival. " 01/01/2020 - "Cell Counting Kit-8 (CCK-8) assay was performed to evaluate proliferation viability of breast cancer cells under pristimerin treatment. " 01/01/2020 - "Pristimerin Suppressed Breast Cancer Progression via miR-542-5p/DUB3 Axis."
3.	Pancreatic Neoplasms (Pancreatic Cancer) 05/01/2014 - "Thus, the mechanistic understanding of the antitumor activity of pristimerin could facilitate in vivo efficacy studies of pristimerin for pancreatic cancer." 01/01/2012 - "Taken together, these data provide the first evidence that pristimerin has strong potential for development as a novel agent against pancreatic cancer." 01/01/2012 - "Treatment with pristimerin decreased the cell proliferation of all three pancreatic cancer cells in a dose- and time-dependent manner. " 01/01/2021 - "Pristimerin synergizes with gemcitabine through abrogating Chk1/53BP1-mediated DNA repair in pancreatic cancer cells." 01/01/2012 - "Pristimerin causes G1 arrest, induces apoptosis, and enhances the chemosensitivity to gemcitabine in pancreatic cancer cells."
4.	Inflammation (Inflammations) 04/10/2023 - "Besides, PD-L1+ exosomes carrying pristimerin treatment alleviated ferroptosis-related changes in psoriatic skin, thereby dampening excessive inflammation and, in turn, decreasing the abnormal proliferation of keratinocytes in psoriatic lesions. " 03/02/2020 - "Attenuation of pristimerin on TNF-α-induced endothelial inflammation." 03/15/2018 - "Pristimerin administration decreased inflammation and proliferation induced by AOM/DSS in colon tissue. " 12/01/2014 - "Pristimerin effectively inhibited both arthritic inflammation and cartilage and bone damage in the joints. " 01/01/2008 - "Pristimerin is a natural product derived from the Celastraceae and Hippocrateaceae families that were used as folk medicines for anti inflammation in ancient times. "
5.	Carcinogenesis 03/15/2018 - "Overall, this study indicates the potential value of pristimerin in suppressing colon tumorigenesis." 01/01/2020 - "These results suggest that pristimerin is a potent agent for preventing colon inflammation and carcinogenesis." 03/15/2018 - "However, the therapeutic role of pristimerin in colitis-associated colorectal carcinogenesis is unknown. " 03/15/2018 - "Pristimerin, a naturally occurring triterpenoid, attenuates tumorigenesis in experimental colitis-associated colon cancer." 01/01/2020 - "In HCT116 colon cancer xenografts and APCmin/+ mice, which undergo spontaneous intestinal tumorigenesis, administration of pristimerin reduced the tumor progression and decreased the expression of phosphorylated GSK3β Ser 9, β-catenin, cyclin D1 and c-Myc. "

Related Drugs and Biologics

1.	Triterpenes
2.	Paclitaxel (Taxol)
3.	quinone methide
4.	Cytokines
5.	Azoxymethane
6.	Cyclin-Dependent Kinases (cdk Proteins)
7.	Cyclins
8.	Interleukin-6 (Interleukin 6)
9.	Indomethacin (Indometacin)
10.	Gemcitabine

Related Therapies and Procedures

1.	Therapeutics
2.	Ovariectomy (Oophorectomy)
3.	Chinese Traditional Medicine (Traditional Chinese Medicine)
4.	Tenotomy
5.	Drug Therapy (Chemotherapy)