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natterin

aerolysin-like fish toxin

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Venoms: 4328
  - Fish Venoms: 14
    - natterin: 3
Biological Factors: 2472
- Biological Toxins: 20
  - Venoms: 4328
    - Fish Venoms: 14
      - natterin: 3
  - Marine Toxins: 124
    - Fish Venoms: 14
      - natterin: 3
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - natterin: 3

Experts

1.	Andrade-Barros, Aline Ingrid: 2 articles (03/2022 - 02/2021)
2.	Balogh, Eniko: 2 articles (03/2022 - 02/2021)
3.	Lima, Carla: 2 articles (03/2022 - 02/2021)
4.	Lopes-Ferreira, Monica: 2 articles (03/2022 - 02/2021)
5.	Ryffel, Bernhard: 2 articles (03/2022 - 02/2021)
6.	Bernardo, Jefferson Thiago Gonçalves: 1 article (03/2022)
7.	Quesniaux, Valerie F: 1 article (03/2022)
8.	Conceiçao, Katia: 1 article (02/2021)
9.	Falcao, Maria Alice Pimentel: 1 article (02/2021)
10.	Grund, Lidiane Zito: 1 article (02/2021)

Related Diseases

1.	Peritonitis 03/25/2022 - "Employing a peritonitis mouse model, we found that the deficiency of the tlr2/tlr4, myd88 and trif results in decreased neutrophil influx to peritoneal cavities of mice, indicative that in addition to MyD88, TRIF contributes to neutrophilia triggered by TLR4 engagement by Natterin. " 02/01/2021 - "Using a combination of pharmacologic and genetic loss-of-function approaches we conduct a systematic investigation of the regulatory mechanisms that control Natterin-induced neutrophilic inflammation in the peritonitis model. "
2.	Inflammation (Inflammations) 02/01/2021 - "Our data confirmed the capacity of Natterin to induce a strong and sustained neutrophilic inflammation leading to systemic inflammatory lung infiltration and revealed overlapping regulatory paths in its control. " 02/01/2021 - "Using a combination of pharmacologic and genetic loss-of-function approaches we conduct a systematic investigation of the regulatory mechanisms that control Natterin-induced neutrophilic inflammation in the peritonitis model. " 02/01/2021 - "The inflammation triggered by Natterin was a gasdermin-D-dependent inflammasome process, despite the cells did not die by pyroptosis. " 02/01/2021 - "Natterin an aerolysin-like fish toxin drives IL-1β-dependent neutrophilic inflammation mediated by caspase-1 and caspase-11 activated by the inflammasome sensor NLRP6."
3.	Edema (Dropsy) 08/01/2005 - "The isolated protein, named natterin, was able to induce edema, nociception and cleave human kininogen and kininogen-derived synthetic peptides, releasing kallidin (Lys-bradykinin). "
4.	Bites and Stings (Sting) 03/25/2022 - "Finally, using cgas KO, sting KO, or irf3 KO mice we found that recruitment of neutrophils to peritoneal cavities was virtually abolished in response to Natterin. " 03/25/2022 - "Natterin-Induced Neutrophilia Is Dependent on cGAS/STING Activation via Type I IFN Signaling Pathway." 03/25/2022 - "In this work, we investigated whether Natterin activates mitochondrial damage, resulting in self-DNA leaks into the cytosol, and whether the DNA sensor cGAS and STING pathway participate in triggering the innate immune response. "

Related Drugs and Biologics

1.	Inflammasomes
2.	Proteins (Proteins, Gene)
3.	Peptides (Polypeptides)
4.	Kininogens (Kininogen)
5.	Kallidin
6.	DNA (Deoxyribonucleic Acid)
7.	aerolysin