5-oxo-eicosatetraenoic acid

10/01/2017 - "Our study demonstrates significant up-regulation of 5-oxo-ETE synthesis in HDM-allergic patients and indicates possible involvement of that mediator in the pathogenesis of allergic asthma."
01/01/2020 - "These data provide the first evidence for a pathophysiological role for 5-oxo-ETE in mammals and suggest that potent and selective OXE receptor antagonists such as S-Y048 may be useful therapeutic agents in asthma and other eosinophilic diseases."
08/01/2015 - "We conclude that feline leukocytes synthesize and respond to 5-oxo-ETE, which could potentially play an important role in feline asthma, a common condition in this species. "
08/01/2015 - "We found that feline peripheral blood leukocytes synthesize 5-oxo-ETE and that physiologically relevant levels of 5-oxo-ETE are present in bronchoalveolar lavage fluid from cats with experimentally induced asthma. "
05/09/2013 - "We have designed and synthesized a 5-oxo-ETE receptor antagonist, the purpose of which is to prevent eosinophil migration to the lung during an asthma attack and thereby reduce asthma symptoms."

02/03/2020 - "Conclusion: A reduction in body mass by more than 7% but not by less than 7% revealed a significant improvement in steatosis stage; waist circumference; fatty liver index; and levels of triglycerides, cholesterol, 5-oxo-ETE and LTXA-4."

04/01/2015 - "5-Oxo-ETE also appears to stimulate tumor cell proliferation and may also be involved in cancer. "
10/01/2005 - "5-Oxo-ETE analogs and the proliferation of cancer cells."
06/01/2011 - "5-Oxo-ETE may be an attractive target in cancer therapy."
10/01/2013 - "Because of its potent effects on eosinophils, 5-oxo-ETE may be an important mediator in asthma, and, because of its proliferative effects, may also contribute to tumor progression. "
11/01/2023 - "In this work, we mined the ZINC15 database, using QSAR, for natural compounds able to signal through Gαi and Gβγ simultaneously, mimicking testosterone actions, as well as for specific Gβγ interactors, inhibiting 5-oxo-ETE tumor promoting actions. "

12/20/2021 - "Knock-down of OXER1 or inhibition of 5-oxo-ETE synthesis led to decreased migration of cells and a prolongation of healing, in culture prostate cancer cell monolayers, with a substantial modification of actin cytoskeleton and a decreased filopodia formation. "
06/01/2011 - "In the present study, we found that PC3 prostate cancer cells and cell lines derived from breast (MCF7) and lung (A-427) cancers contain 5-hydroxyeicosanoid dehydrogenase (5-HEDH) activity and have the ability to synthesize 5-oxo-ETE from its precursor 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) when added as an exogenous substrate. "

01/01/2022 - "This study provides the first evidence that 5-oxo-ETE may play an important role in inducing allergen-induced pulmonary inflammation and could also be involved in regulating MUC5AC in goblet cells. "