HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

OREX-1019

compound that mimics the pharmacology of the buprenorphine/naltrexone combination

Also Known As:

BU10119

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Belli, Barbara: 1 article (01/2020)
2.	Cami-Kobeci, Gerta: 1 article (01/2020)
3.	Flynn, Peter: 1 article (01/2020)
4.	France, Charles P: 1 article (01/2020)
5.	Gerak, Lisa R: 1 article (01/2020)
6.	Husbands, Stephen M: 1 article (01/2020)
7.	Maguire, David R: 1 article (01/2020)

Related Diseases

1.

Opioid-Related Disorders (Opiate Addiction)

01/01/2020 - "This study evaluated, in rhesus monkeys, the therapeutic potential of OREX-1019 for treating opioid use disorder. "
01/01/2020 - "SIGNIFICANCE STATEMENT: The novel opioid OREX-1019 potentially provides an improved relapse prevention agent for use in opioid use disorder. "
01/01/2020 - "These results confirm that OREX-1019 has little or no efficacy at μ opioid receptorsand has low abuse potential, and, combined with promising safety (clean profile vs. other off-target proteins including the hERG (human ether-a-go-go-related gene) K+ channel) and pharmacokinetic data (supporting administration by subcutaneous or sublingual routes, but with low oral bioavailability), suggest it could be a safe and effective alternative to current treatments for opioid use disorders particularly as applied to relapse prevention. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Ether (Diethyl Ether)
3.	Opioid Analgesics (Opioids)

Related Therapies and Procedures

1.	Secondary Prevention