IR-783

near‑infrared heptamethine cyanine dye

Also Known As:

2-(2-(2-Chloro-3-(2-(1,3-dihydro-3,3-dimethyl-1-(4-sulfobutyl)-2H-indol-2-ylidene)-ethylidene)-1-cyclohexen-1-yl)-ethenyl)-3,3-dimethyl-1-(4-sulfobutyl)-3H-indolium hydroxide, inner salt sodium salt

Networked: 8 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 205
      - IR-783: 8

Experts

1.	Chung, Leland W K: 3 articles (01/2014 - 05/2010)
2.	Wang, Ruoxiang: 3 articles (01/2014 - 05/2010)
3.	Zhau, Haiyen E: 3 articles (01/2014 - 05/2010)
4.	Hu, Changpeng: 2 articles (08/2019 - 01/2018)
5.	Huang, Jingbin: 2 articles (08/2019 - 01/2018)
6.	Lai, Wenjing: 2 articles (08/2019 - 01/2018)
7.	Li, Guobing: 2 articles (08/2019 - 01/2018)
8.	Liu, Wuyi: 2 articles (08/2019 - 01/2018)
9.	Liu, Yali: 2 articles (08/2019 - 01/2018)
10.	Sheng, Fangfang: 2 articles (08/2019 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "IR-783 is a kind of heptamethine cyanine dye that exhibits imaging, cancer targeting and anticancer properties. " 05/15/2010 - "IR-783 and MHI-148 were investigated for their ability to accumulate in human cancer cells, tumor xenografts, and spontaneous mouse tumors in transgenic animals. " 05/15/2010 - "In this study, we show the preferential uptake and retention of two hepatamethine cyanine dyes, IR-783 and MHI-148, in tumor cells and tissues. " 01/01/2022 - "The NIR-II-emissive dye IR-783 and chemotherapy drug doxorubicin (DOX) were encapsulated into liposomes, and the tumor-targeting peptide TMTP1 (a polypeptide with a sequence of cyclic ASN Val Val Arg Gln Cys) was conjugated to the surface of the liposomes to form IR-783-DOX-TMTP1 nanoparticles (NPs) via self-assembly methods. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "Our study uncovered the molecular mechanism of the anti-breast cancer effects of IR-783 and provided novel perspectives for the application of IR-783 in the treatment of breast cancer." 01/01/2018 - "In this study, we showed that IR-783 inhibits cell viability and induces mitochondrial apoptosis in human breast cancer cells. " 08/01/2019 - "IR-783 inhibits breast cancer cell proliferation and migration by inducing mitochondrial fission." 01/01/2018 - "Taken together, these findings suggest that IR-783 induces apoptosis in human breast cancer cells by increasing Drp1-mediated mitochondrial fission. "
3.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2019 - "In the present study, we proved that IR-783 has potential for detecting cervical cancer cells in clinical specimens and in circulating blood. " 01/01/2019 - "The results revealed that IR-783 dye could be specifically uptaken by cultured cervical cancer cells, human cervical cancer cell-spiked whole blood, human cervical cancer xenografts and freshly harvested human cervical cancer tissue, but not by normal cell tissues. " 01/01/2019 - "The imaging was investigated in cervical cancer cells for detecting the uptake, accumulation and subcellular localization of IR-783 dye. " 01/01/2019 - "Role of near-infrared heptamethine cyanine dye IR-783 in diagnosis of cervical cancer and its mechanism." 01/01/2019 - "The goal of this study was to evaluate the value of the IR-783 dye, a near-infrared heptamethine carbocyanine, as an imaging agent for rapid detection of human cervical cancer and the underlying mechanism of IR-783 mediated imaging. "
4.	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 01/01/2018 - "Furthermore, we found that IR-783 induced dynamin-related protein 1 (Drp1) translocation from the cytosol to the mitochondria, increased the expression of mitochondrial fission proteins mitochondrial fission factor (MFF) and fission-1 (Fis1), and decreased the expression of mitochondrial fusion proteins mitofusin1 (Mfn1) and optic atrophy 1 (OPA1). "
5.	Prostatic Neoplasms (Prostate Cancer) 01/01/2014 - "Peripheral blood mononuclear cells (PBMCs) from 40 patients with localized prostate cancer together with 5 patients with metastatic disease were stained with IR-783, the prototype heptamethine cyanine dye. "

Related Drugs and Biologics

1.	Coloring Agents (Dyes)
2.	Carbocyanines
3.	MHI-148
4.	heptamethine cyanine dye
5.	Dynamins (Dynamin)
6.	Mitochondrial Proteins (Mitochondrial Protein)
7.	Proteins (Proteins, Gene)
8.	Peptides (Polypeptides)
9.	Liposomes (Liposome)
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)