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CAY10591

a SIRT1 NAD-dependent histone deacetylase activator

Also Known As:

2-amino-N-cyclopentyl-1-(3-methoxypropyl)pyrrolo(3,2-b)quinoxaline-3-carboxamide

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclopentanes: 58
        CAY10591: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - CAY10591: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - CAY10591: 3

Experts

1.	Amadio, Patrizia: 1 article (05/2017)
2.	Banfi, Cristina: 1 article (05/2017)
3.	Barbieri, Silvia S: 1 article (05/2017)
4.	Brioschi, Maura: 1 article (05/2017)
5.	Colombo, Gualtiero I: 1 article (05/2017)
6.	Gianellini, Sara: 1 article (05/2017)
7.	Ieraci, Alessandro: 1 article (05/2017)
8.	Lee, Francis S: 1 article (05/2017)
9.	Parolari, Alessandro: 1 article (05/2017)
10.	Tarantino, Eva: 1 article (05/2017)

Related Diseases

1.	Colitis 11/01/2014 - "Cay10591 prevented and cured experimental colitis whereas Ex527 exacerbated disease by modulating T cell-derived cytokine response. "
2.	Thrombosis (Thrombus) 05/07/2017 - "SIRT1 activation, using resveratrol and/or CAY10591, prevented thrombus formation and restored the physiological levels of coagulation and of platelet markers in BDNFMet/Met mice and/or cells transfected with the Met allele. "
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/2017 - "Our findings suggest that CAY10591 suppresses cell growth and invasion/migration activity in gingival squamous cell carcinoma Ca9-22 cells."
4.	Carcinoma (Carcinomatosis) 01/01/2017 - "Here, we examined the effects of the SIRT1 activator CAY10591 in gingival epithelial carcinoma Ca9-22 cells. " 01/01/2017 - "CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells."

Related Drugs and Biologics

1.	Cytokines
2.	Sirtuin 1
3.	Resveratrol