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ZKK-13

has cytotoxic and pro-apoptotic activity towards glioma-derived cell lines

Also Known As:

N,N'-diisopropyl-S-(2,3,4,5,6-pentabromobenzyl)isothiouronium bromide

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Thiourea: 362
      - Isothiuronium: 13
        ZKK-13: 2
- Sulfur Compounds: 278
  - Thiourea: 362
    - Isothiuronium: 13
      - ZKK-13: 2

Experts

1.	Kazimierczuk, Zygmunt: 2 articles (01/2018 - 11/2013)
2.	Koronkiewicz, Mirosława: 1 article (01/2018)
3.	Matyja, Ewa: 1 article (01/2018)
4.	Ostrowski, Robert P: 1 article (01/2018)
5.	Pucko, Emanuela: 1 article (01/2018)
6.	Chilmonczyk, Zdzislaw: 1 article (11/2013)
7.	Koronkiewicz, Miroslawa: 1 article (11/2013)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/01/2013 - "In this study, we examined pro-apoptotic and cytostatic effects of three CK2 inhibitors: one known, 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole (DMAT) and two new: 2-(4-methylpiperazin-1-yl)-4,5,6,7-tetrabromo-1H-benzimidazole (MPT) and 2-aminoethyleneamino-4,5,6,7-tetrabromo-1H-benzimidazole (AEAT), as well as of certain S-2,3,4,5,6-pentabromobenzylisothiouronium bromides: ZKK-3, ZKK-9, ZKK-13, against the human acute myelogenous leukemia cell line (KG-1). "
2.	Glioma (Gliomas) 01/01/2018 - "Two pentabromobenzyl isothiourea bromide derivatives, ZKK-13 and N,N,N'-trimethyl-ZKK1 (TRIM), exhibited the most potent cytotoxic and proapoptotic efficacies against human glioma-derived cells, even at a very low concentration (1 μM). "

Related Drugs and Biologics

1.	Bromides
2.	Cytostatic Agents
3.	2- dimethylamino- 4,5,6,7- tetrabromo- 1H- benzimidazole